Recombinant adenovirus, pU6-(Human NLRP3), Overexpression(CAT#: AdV-GTOH0053WQ)

The product is an adenovirus vector containing the insertion of NLRP3 gene. This gene encodes a pyrin-like protein containing a pyrin domain, a nucleotide-binding site (NBS) domain, and a leucine-rich repeat (LRR) motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome complex. The product is suitable for stable overexpression of exogenous gene in various types of cells and can be used in gene therapy research and development.

Specifications
Family Adenoviridae
Species Adenovirus
Tropism Both nondividing and dividing cells
Insert NLRP3
Related Target/Protein Human NLRP3
NCBI RefSeq NM_001079821
Alternative Names AII, AVP, FCU, MWS, FCAS, KEFH, CIAS1, FCAS1, NALP3, C1orf7, CLR1.1, DFNA34, PYPAF1, AGTAVPRL
Titer >1.00E+10 PFU/mL
Related Diseases familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), chronic infantile neurological cutaneous and articular (CINCA) syndrome, and neonatal-onset multisystem inflammatory disease (NOMID)
Application Overexpression
Target Gene
Gene ID 114548
Uniprot ID Q96P20

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