Antisense Oligonucleotides (ASOs) Products for Cytomegalovirus Retinitis
Cytomegalovirus retinitis, also known as CMV retinitis, is a serious viral eye infection of the retina. It is caused by human cytomegalovirus and most often found in people with weakened immune systems. Over the last years, antisense oligonucleotides (ASOs) have gained attention as a therapeutic tool for the treatment of ocular diseases such as CMV retinitis. Depending on the complementary to their target, the ASOs can result in modulation of pre-mRNA splicing, or in a (allele-specific) degradation of target transcripts. It has documented that ASO-based strategies are capable of correcting splice defects resulting from deep-intronic mutations and inducing allele-specific degradation of mutant transcripts in ocular diseases. Some antisense compounds have been designed to inhibit CMV replication, which possesses antiviral activity that favors their use as therapeutic agents in the treatment of CMV retinitis.
Creative Biolabs is a world-renowned service provider for antisense oligonucleotides therapy development. We provide a variety of top-quality ASO products for cytomegalovirus retinitis therapy. A series of stringent criteria are applied to implement quality control of antisense products in order to guarantee reliability. We are dedicated to providing the best-characterized antisense therapy service to help our customers and expedite their project application. Please feel free to contact us by e-mail for a quote and further discussion with our scientists.
Reference
- Collin, R. and Garanto, A. (2017). Applications of antisense oligonucleotides for the treatment of inherited retinal diseases. Current Opinion in Ophthalmology. 28(3), pp.260-266.
