shRNA Lentivirus (self-inactivating), pU6-(Peo1-shRNA-Seq1)(CAT#: LV-SI1840WQ)

This product is a Peo1-shRNA encoding Lentivirus, which is based on HIV-1 serotype. The gene Peo1 encodes a hexameric DNA helicase which unwinds short stretches of double-stranded DNA in the 5' to 3' direction and, along with mitochondrial single-stranded DNA binding protein and mtDNA polymerase gamma, is thought to play a key role in mtDNA replication. The expression of Peo1-shRNA leads to target gene silencing and this product can be used in gene therapy research and development.

Specifications
Family Retroviridae
Species Lentivirus
Serotype HIV-1
Backbone Lenti-SIN
Tropism Both nondividing and dividing cells
Insert Peo1-shRNA-Seq1
Related Target/Protein Peo1
Region CDS
TargetSeq CGACTGAAATCCGCCAGTATT
NCBI RefSeq NM_153796
Alternative Names PEO; TWNK; SCA8; ATXN8; IOSCA; PEOA3; SANDO; TWINL; MTDPS7; PRLTS5; C10orf2
Titer >1*10^10 GC/mL
Related Diseases Infantile onset spinocerebellar ataxia (IOSCA), Progressive external ophthalmoplegia (PEO), Several mitochondrial depletion syndromes
Target Gene
Gene ID 56652
Uniprot ID Q96RR1

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