shRNA Lentivirus (self-inactivating), pU6-(PIGW-shRNA-Seq2)(CAT#: LV-SI0140WQ)

This product is a PIGW-shRNA encoding Lentivirus, which is based on HIV-1 serotype. The protein encoded by PIGW gene is an inositol acyltransferase that acylates the inositol ring of phosphatidylinositol. Defects in this gene are a cause of the age-dependent epileptic encephalopathy West syndrome as well as a syndrome exhibiting hyperphosphatasia and cognitive disability (HPMRS5). The expression of PIGW-shRNA leads to target gene silencing and this product can be used in gene therapy research and development.

Specifications
Family Retroviridae
Species Lentivirus
Serotype HIV-1
Backbone Lenti-SIN
Tropism Both nondividing and dividing cells
Insert PIGW-shRNA-Seq2
Related Target/Protein PIGW
Region 3UTR
TargetSeq GCAACAGTGTTAACCATATTT
NCBI RefSeq NM_178517
Alternative Names Gwt1; HPMRS5
Titer >1*10^10 GC/mL
Related Diseases Hyperphosphatasia and mental retardation syndrome
Target Gene
Gene ID 284098
Uniprot ID Q7Z7B1

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