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Oligonucleotide-peptide Conjugation Service

Oligonucleotide-peptide conjugates always exhibit a strong biological effect in a variety of applications, and they can be used to improve both cellular specificity and intracellular delivery of antisense or antigene compounds or to modify functions of the peptide or protein. As a service provider in bioconjugation, we have successfully accomplished numerous challenging oligonucleotide conjugation projects. Now, Creative Biolabs can offer high-quality oligonucleotide-peptide conjugation services by using the raw materials containing synthetic oligonucleotide and peptide provided by our customers all over the world.

Oligonucleotide-peptide Conjugation at Creative Biolabs

Oligonucleotide-peptide conjugates are chimeric molecules composed of synthesized oligonucleotide (DNA or RNA) linked to the peptide. Oligonucleotide-peptide chemical conjugation can add some biological and biophysical properties of peptides to oligonucleotides. Up to now, a considerable number of different conjugates possibilities have been developed and investigated extensively. Creative Biolabs provides a wide variety of oligonucleotide synthesis scales, modifications, conjugations, and purifications to customize your oligonucleotide-peptide conjugates to meet exacting requirements.

The potential sites available for the attachment of peptides. Figure 2. The potential sites available for the attachment of peptides. (Aviñó, 2011)

Applications of Oligonucleotide-peptide Conjugation

These oligonucleotide-peptide conjugates are used in a variety of potential biological applications, which in fields ranging from therapeutics to nanotechnology. One of the most frequently and increasingly important applications of such chemical conjugation is to improve the cellular delivery of antisense or antigene compounds and therapeutic potential of these agents, where the peptide acts as an exceptionally versatile carrier. Oligonucleotides have been successfully attached to many peptides to enhance the cellular membrane permeability and study the molecular requirements for enzyme activity. Moreover, oligonucleotide-peptide conjugation is also used to allow the spatial immobilization of conjugates on DNA arrays or to modify peptide functions with oligonucleotide as regulatory elements. In addition, oligonucleotide-peptide conjugates have been served as the possible molecular tools (e.g., epitope mapping) and used as the testing tool in several sensing systems.

The intracellular delivery of oligonucleotide conjugates. Figure 3. The intracellular delivery of oligonucleotide conjugates. (Juliano, 2012)

Features of Our Service

Creative Biolabs is a leading service provider that tailors the best-fit proposal for oligonucleotide-peptide conjugation to meet your expected objectives. If you are interested in learning more about our capacity for oligonucleotide conjugation, please do not hesitate to contact us.


  1. Aviñó, A.; et al. (2011). Synthesis of Oligonucleotide-Peptide Conjugates for Biomedical and Technological Applications. Bioconjugation Protocols. 223-238.
  2. Juliano, R, L.; et al. (2012). The chemistry and biology of oligonucleotide conjugates. Accounts of Chemical Research. 45(7): 1067-1076.

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