shRNA Adeno-associated Virus Serotype 2, pU6-(WDR74-shRNA-Seq2)(CAT#: AAV-SI0452WQ)

This product is a WDR74-shRNA encoding AAV, which is based on AAV-2 serotype. The WDR74 gene participates in an early cleavage of the pre-rRNA processing pathway in cooperation with NVL and is required for blastocyst formation, is necessary for RNA transcription, processing and/or stability during preimplantation development. The expression of WDR74-shRNA leads to target gene silencing and this product can be used in gene therapy research and development.

Specifications
Family Parvoviridae
Species Adeno-associated virus (AAV)
Serotype AAV-2
Backbone AAV-2
Tropism CNS, muscle, liver, brain, eye
Insert WDR74-shRNA-Seq2
Related Target/Protein WDR74
Region CDS
TargetSeq GACACAGAGACAGATGAACTT
NCBI RefSeq NM_018093
Alternative Names Nsa1
Titer >1*10^10 GC/mL
Related Diseases Mammary adenocarcinoma
Target Gene
Gene ID 54663
Uniprot ID Q6RFH5

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