Recombinant adeno-associated virus type 2, pU6-(Human slug), Overexpression(CAT#: AAV-GTOH0030WQ)
The product is an adeno-associated virus type 2 (AAV2) vector containing the insertion of slug gene. This gene encodes a member of the Snail family of C2H2-type zinc finger transcription factors. The encoded protein acts as a transcriptional repressor that binds to E-box motifs and is also likely to repress E-cadherin transcription in breast carcinoma. The product is suitable for stable overexpression of exogenous gene in various types of cells and can be used in gene therapy research and development.
| Specifications | |
|---|---|
| Family | Parvoviridae |
| Species | Adeno-associated virus (AAV) |
| Serotype | AAV2 |
| Tropism | Both nondividing and dividing cells |
| Insert | slug |
| Related Target/Protein | Human SNAI2 |
| NCBI RefSeq | NM_003068 |
| Alternative Names | SLUG, WS2D, SLUGH, SLUGH1, SNAIL2 |
| Titer | >1.00E+12 v.g./mL |
| Related Diseases | breast carcinoma, sporatic cases of neural tube defects |
| Application | Overexpression |
