siRNA, Anti-ATP8B1, 2'-F/2'-OMe/2'-MOE/Ribo/Backbone-modified(CAT#: SIRGT16322WQ-2OMe)

The product SIRGT16322WQ-2OMe is a type of small interfering RNA (siRNA) that targets ATP8B1 gene and regulates the expression of gene. The siRNA interferes with the expression of ATP8B1 gene with complementary nucleotide sequences by degrading mRNA after transcription, preventing translation. The siRNA is designed with 2ʹ-O-methyl (2'-OMe) modification to provide increased stability, increased specificity and reduced immunogenicity. It has potential applications in RNA interference (RNAi) and gene therapy development.

Specifications
NCBI RefSeq NM_005603.5
Alternative Names ATPIC; BRIC; FIC1; ICP1; PFIC; PFIC1
Related Diseases Cholestasis, Progressive Familial Intrahepatic
Purification HPLC
Target Gene
Gene ID 5205
Uniprot ID O43520
Sub Cat Target Species Modification Scale  
SIRGT17322WQ-2F ATP8B1 Human 2ʹ-deoxy-2ʹ-fluoro (2'-F) Inquiry
SIRGT18322WQ-2MOE ATP8B1 Human 2'-O-methoxyethyl (2'-MOE) Inquiry
SIRGT16322WQ-RB ATP8B1 Human Ribo-modified Inquiry
SIRGT17322WQ-BB ATP8B1 Human Backbone-modified Inquiry

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