Introduction of GHRHR
The growth hormone releasing hormone receptor (GHRHR) is a G protein-coupled receptor encoded by GHRHR. It leads to the synthesis and release of growth hormone after binding to growth hormone-releasing hormone. GHRHR activates Gs protein and cascades cAMP through adenylate cyclase, stimulating growth hormone cell growth, growth hormone gene transcription, and growth hormone secretion.
|Basic Information of GHRHR|
|Protein Name||Growth hormone-releasing hormone receptor|
|Aliases||GHRH receptor, Growth hormone-releasing factor receptor, GRF receptor, GRFR|
|Organism||Homo sapiens (Human)|
Function of GHRHR Membrane Protein
The GHRHR is coupled to the G protein of adenylyl cyclase. GHRHR activates the Gs protein after binding to hormones, and causes a cascade of cAMP via Adenylate cyclase, stimulating somatotroph cell growth, growth hormone gene transcription, growth hormone synthesis, and secretion. Growth hormone-releasing hormone (GHRH) and the receptor, GHRHR, constitute important components of the hypothalamus-pituitary growth axis and act on the downstream growth hormone (GH).
Fig.1 Crystal structure of the extracellular domain of human GHRHR.
Application of GHRHR Membrane Protein in Literature
This article reports that growth hormone releasing hormone (GHRH) and its receptor GHRHR are important components of the hypothalamic-pituitary growth axis and can act on growth hormone (GH).
This article reveals that Sporadic growth hormone deficiency may be caused by environmental brain damage or dysplasia, GHRHR mutation patients and phenotype and biochemistry are indistinguishable from other forms of IGHD.
The article reveals that the gene encoding GHRHR is involved in isolated growth hormone deficiency (IGHD), which plays a key role in GH synthesis and pituitary secretion through its ligand (GHRH).
This article shows that Growth hormone releasing hormone (GHRH) receptors expressed by cardiomyocytes and cardiac stem cells (CSCs) are activated to improve the injury response after myocardial infarction (MI).
This article evaluates that Cardiac repair of growth hormone releasing hormone agonist (GHRH-As) after myocardial infarction (MI) in rats is regulated by activating GHRH signaling pathways in the heart.
GHRHR Preparation Options
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