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HighlightsIntroduction of GJB2
Gap junction beta-2 protein (GJB2) is a protein encoded by the GJB2 gene. It is also known as connexin-26(cx26). GJB2 is involved in the movement of small metabolites and ions between the neighboring cells. The gap junction is first characterized by an electron microscope and has a regional specific structure on the plasma membrane contacting the attached cells. These structures have been shown to consist of cells to cell channels. Proteins purified from the rich gap junctions of different tissues, called connexins, are different. Connexins are specified by their molecular mass. Another nomenclature divides connexins into two categories: alpha and beta, based on sequence similarity at nucleotide and amino acid levels.
| Basic Information of GJB2 | |
| Protein Name | Gap junction beta-2 protein |
| Gene Name | GJB2 |
| Aliases | Connexin-26 |
| Organism | Homo sapiens (Human) |
| UniProt ID | P29033 |
| Transmembrane Times | 4 |
| Length (aa) | 226 |
| Sequence | MDWGTLQTILGGVNKHSTSIGKIWLTVLFIFRIMILVVAAKEVWGDEQADFVCNTLQPGCKNVCYDHYFPISHIRLWALQLIFVSTPALLVAMHVAYRRHEKKRKFIKGEIKSEFKDIEEIKTQKVRIEGSLWWTYTSSIFFRVIFEAAFMYVFYVMYDGFSMQRLVKCNAWPCPNTVDCFVSRPTEKTVFTVFMIAVSGICILLNVTELCYLLIRYCSGKSKKPV |
Function of GJB2 Membrane Protein
Mutation of the GJB2 gene-encoded protein Cx26 in homozygous and heterozygous states is an important part of the recessive form of chromosomes in different populations. This genetic defect leads to the most common congenital deafness in developed countries, called DFNB1 (also known as connexin 26 deafness or gjb2-related deafness). Through the regulation of the cell cycle, GJB2 also plays an important role in tumor suppression. Abnormal expression of GJB2, associated with several types of human cancer, may be a prognostic factor for cancers such as colorectal cancer, breast cancer, and bladder cancer. In addition, it is recommended to promote the development of cancer by promoting cell migration and invasion, and to promote the development of cancer by stimulating the self-renewal capacity of cancer stem cells.
Fig.1 The structure of Gap junction beta-2 protein.
Application of GJB2 Membrane Protein in Literature
The results show that GJB2 has high expression in α-SMA positive myofibroblast-rich nodules, indicating that connexins could be a novel treatment target for the treatment of DD.
This article implies that GJB2 inhibit transformed growth of HeLa cells.
The results suggest that the GJB2 and Connexin-30 genes are intimately connected to Deaf culture.
The previous researches indicate that mutations of Cx26 (connexin 26) are the most frequent cause of genetic deafness.
This article indicates that expression of Cx26 in HeLa cells selectively enhances wound healing in a manner that is dependent on intercellular coupling.
GJB2 Preparation Options
To obtain the soluble and functional target protein, the versatile Magic™ membrane protein production platform in Creative Biolabs enables many flexible options, from which you can always find a better match for your particular project. Aided by our versatile Magic™ anti-membrane protein antibody discovery platform, we also provide customized anti-GJB2 antibody development services.
Creative Biolabs' skillful scientists are glad to leverage our expertise and advanced technologies to help you with the member protein research. If you are interested, please feel free to contact us for more details.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
