Introduction of GLP1R
The glucagon-like peptide 1 receptor (GLP1R) is a receptor protein encoded by gene GLP1R. GLP1R consists of two domains, an extracellular (ECD) that binds the C-terminal helix of GLP-1, and a transmembrane (TMD) domain that binds the N-terminal region of GLP-1. It was found on beta cells of the pancreas and involved in the control of blood sugar level by enhancing insulin secretion. It also stimulates glucose-induced insulin secretion.
|Basic Information of GLP1R|
|Protein Name||Glucagon-like peptide 1 receptor|
|Organism||Homo sapiens (Human)|
Function of GLP1R Membrane Protein
GLP1R is a receptor protein found on beta cells of the pancreas. This receptor, which functions at the cell surface, becomes internalized in response to GLP-1 and GLP-1 analogs, and it plays an important role in the signaling cascades leading to insulin secretion. Activated GLP1R stimulates the adenylyl cyclase pathway which results in increased insulin synthesis and release of insulin. GLP1R, expressed in the brain, is involved in the control of appetite. GLP1R, expressed in stretch responsive vagal neurons in the stomach and intestinesneurons, innervates stomach muscle and can communicate with additional organ systems changing breathing and heart rate due to activation.
Fig.1 Structure of protein GLP1R.
Application of GLP1R Membrane Protein in Literature
This paper reports that glucose and body weight is regulated by the brain and the GLP1R mediator changes in neurons, but it is necessary for non-glucose reduction.
This paper proposes that glucagon-like peptide 1 (GLP-1) can mediate the global stress response in the hypothalamic paraventricular circulation.
This article reveals that improvement in renal fibrosis is mediated by exendin-4 via the miR-192-GLP1R pathway.
This article shows that functional disruption of the Glp1r results in exercise-induced hyperglycemia associated with an excessive increase in glucagon secretion and HGP. These results suggest an essential role for basal Glp1r signaling in the suppression of alpha cell secretion during exercise.
This article evaluates that glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) play important roles in insulin secretion through their receptors, GLP1R and GIPR.
GLP1R Preparation Options
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