Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsWith over a decade of experience in phage display technology, Creative Biolabs can provide a series of antibody or peptide libraries that are available for licensing or direct screening. These ready-to-use libraries are invaluable resources for isolating target-specific binders for various research, diagnostic or therapeutic applications. Highlights
Creative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
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HighlightsGlucagon-like peptide receptor is a family of G protein-coupled receptors. The glucagon-like peptide 1 receptor (GLP1R) is a receptor protein found on beta cells of the pancreas. Here show the two galanin receptors in humans including GLP1R and GLP2R, which are encoded by GLP1R (present on chromosome 6) and GLP2R (present on chromosome 17).
GLP1R is composed of two domains, one extracellular (ECD) that binds the C-terminal helix of GLP-1, and one transmembrane (TMD) domain that binds the N-terminal region of GLP-1. GLP1R binds glucagon-like peptide-1 (GLP1) and glucagon as its natural endogenous agonists. It is involved in the control of blood sugar level by enhancing insulin secretion. Consequently, GLP1R has been a target for developing drugs usually referred to as GLP1R agonists to treat diabetes. GLP1R is also expressed in the brain, stomach, and intestines. It is involved in the control of appetite, breathing, and heart rate. The diabetic, pancreatic, and neuroprotection implications of GLP1R are also thought to be potential therapies for treating diabetes and energy metabolism abnormalities associated with Huntington's disease affecting the brain and periphery.
Fig.1 The classical (green arrows) and emerging (blue arrow) metabolic actions of GLP-1. (Drucker, 2011)
GLP2R is expressed in the gut and closely related to the glucagon receptor and GLP1R. Glucagon-like peptide-2 (GLP2) is a 33-amino acid proglucagon-derived peptide produced by intestinal enteroendocrine cells. GLP2 stimulates intestinal growth and upregulates villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. Moreover, GLP2 prevents intestinal hypoplasia resulting from total parenteral nutrition.
Aided by cutting-edge Magic™ membrane protein production platform, Creative Biolabs is proud to offer the preparation of these targets in required formats using various strategies, such as detergent micelles, proteoliposomes, nanodiscs, lipoparticles, polymers, stable cell line.
Meanwhile, our Magic™ membrane protein antibody discovery platform can help to discover antibodies against these targets, even fully humanized antibodies, by various approaches including hybridoma technology, phage display technology, etc. We also present DNA immunization service for anti-membrane protein antibody development. Please feel free to contact us for more information.
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