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Glycine Receptor Family

Glycine receptors, also known as GlyRs or GLRs, are members of the Cys-loop family of ligand-gated ion channel receptors and are identified as the key inhibitory receptors of the amino acid neurotransmitter glycine in the mammalian spinal cord and higher brain centers. They are ionotropic receptors that generate the effects through chloride current. Glycine receptors play a crucial role in a range of physiological processes, especially in mediating inhibitory neurotransmission in the spinal cord and brainstem. These receptors can be activated by a variety of simple amino acids such as glycine, β-alanine, and taurine, and can be selectively blocked by the high-affinity competitive antagonist strychnine. Glycinergic signaling is implicated in pain signaling, motor control, vision, hearing, and other brain functions.

Accordingly, new modulators of glycine receptor function are suggested to be of considerable medicinal interest. The identification of novel modulators and agonists emphasizes the relevance of the inhibitory glycine receptor as a therapeutic target. We're concerned here with several glycine receptors that might be of interest to you.

Human Glycine Receptor Members
GLRA1 GLRA2
GLRA3 GLRB

By exploiting our efficient Magic™ membrane protein production platform, scientists in Creative Biolabs are ready to provide the preparation services of these membrane proteins given above in required formats through different strategies, such as detergent micelles, proteoliposomes, nanodiscs, lipoparticles, polymers, with stable cell line.

Magic™ membrane protein production platform – Creative Biolabs

Additionally, Magic™ membrane protein antibody discovery platform in Creative Biolabs can be applied in developing antibodies against these targets, even fully humanized antibodies, by various approaches including hybridoma technology, phage display technology, etc. We also present DNA immunization service for anti-membrane protein antibody development. Please feel free to contact us for more details.

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