Glycine receptors, also known as GlyRs or GLRs, are members of the Cys-loop family of ligand-gated ion channel receptors and are identified as the key inhibitory receptors of the amino acid neurotransmitter glycine in the mammalian spinal cord and higher brain centers. They are ionotropic receptors that generate the effects through chloride current. Glycine receptors play a crucial role in a range of physiological processes, especially in mediating inhibitory neurotransmission in the spinal cord and brainstem. These receptors can be activated by a variety of simple amino acids such as glycine, β-alanine, and taurine, and can be selectively blocked by the high-affinity competitive antagonist strychnine. Glycinergic signaling is implicated in pain signaling, motor control, vision, hearing, and other brain functions.
Accordingly, new modulators of glycine receptor function are suggested to be of considerable medicinal interest. The identification of novel modulators and agonists emphasizes the relevance of the inhibitory glycine receptor as a therapeutic target. We're concerned here with several glycine receptors that might be of interest to you.
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