6,6'-Trehalose dioleate

This compound is a glycolipid, 6,6'-trehalose dioleate (TDO), that has emerged as a functional excipient for reducing the inherent toxicity associated with lipid nanoparticles (LNPs). When incorporated into the LNP formulation, TDO can form stabilizing hydrogen bonds with polar biological molecules. This unique property enables it to partially substitute for the traditional ionizable lipid component, thereby creating a more stable LNP structure.

((1R,2R,3S,4R,5S)-2,3,4-Trihydroxy-5-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-
((oleoyloxy)methyl)tetrahydro-2H-pyran-2-yl)oxy)cyclohexyl)methyl oleate; 6,6'-TDO; 6-O-[(9Z)-1-Oxo-9-octadecen-1-yl]-α-D-glucopyranosyl, α-D-glucopyranoside; D-(+)-Trehalose 6,6'-dioleate

C₄₉H₈₆O₁₃

871.20

Min 95%

Dried by centrifugal evaporation from a solution.

Conforms to structure

Store at -20°C for long term storage.