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Anti-Blood Group Antibody Development Services

Overview

Blood group antibodies, especially those targeting ABO antigens, are central to transfusion safety, transplantation compatibility, and immunohematology research. Naturally occurring antibodies such as anti-A and anti-B can cause severe hemolytic reactions, while alloantibodies to minor antigens complicate transfusion and pregnancy outcomes. These insights underscore the demand for customized, high-specificity antibody solutions.

Anti-blood group antibody development services at Creative Biolabs help you obtain robust, application-ready antibodies through custom immunogen synthesis, advanced antibody engineering, and multi-platform validation. To ensure the successful development of anti-blood group antigen antibodies, we apply a range of well-defined strategies that integrate precision design, advanced platforms, and rigorous validation.

  • Authentic Glycan Immunogens – Chemoenzymatic synthesis of authentic blood group glycans (A, B, H, and subtypes) for structurally defined immunogens.
  • Diverse Development Platforms – Development platforms including hybridoma, phage display, and humanized antibody technologies for diverse formats.
  • Cross-Reactivity Safeguards – Cross-reactivity assessment against related structures, such as Forssman antigen or Lewis antigens, to ensure assay reliability.
  • Functional Validation Models – Functional validation, including complement-binding and hemolysis models, to confirm clinical relevance.

Learn How We Can Accelerate Your Research – Request a Consultation Today.

Service Portfolio

Anti-Blood Group A Antibody Development Service

A specialized service delivering antibodies against blood group A antigens to support transfusion research, diagnostics, and immunology studies.

Anti-Blood Group B Antibody Development Service

A tailored service providing high-quality antibodies targeting blood group B determinants for compatibility testing and clinical assay development.

Anti-Blood Group H Antibody Development Service

A dedicated service focused on generating antibodies against blood group H structures, facilitating rare blood group analysis and serological investigations.

Anti-Blood Group M Antibody Development Service

A custom service for developing antibodies against blood group M antigens to enhance transfusion safety studies and screening applications.

Anti-Blood Group N Antibody Development Service

A professional service delivering precise antibodies against blood group N antigens, offering tools for advanced serology and diagnostic research.

What We Can Offer

Custom Antibody Development

Tailored development of monoclonal, recombinant, or humanized antibodies against ABO and other blood group antigens.

Immunogen and Conjugate Services

Preparation of blood group glycans and conjugation to carriers (BSA, KLH, nanoparticles) for enhanced immunogenicity.

Application-Specific Validation

Antibodies tested and validated across IHC, ELISA, flow cytometry, and diagnostic assay formats.

Comprehensive Data Packages

Full characterization reports including specificity, sensitivity, binding kinetics, and cross-reactivity profiles.

Workflow

01Immunogen Design

Produce authentic glycan immunogens using chemoenzymatic methods, coupled to carriers for optimal immunogenicity.

02Antibody Generation

Apply hybridoma or phage display technologies to discover high-affinity antibody candidates.

03Screening & Validation

Confirm specificity using glycan arrays, ELISA, neutralization assays, and agglutination controls.

04Optimization

Perform affinity maturation and isotype selection to enhance stability and functionality.

05Final Characterization

Deliver full datasets including specificity, sensitivity, cross-reactivity, and recommended use cases.

Required Starting Materials

  • Defined antigen or blood group target (e.g., ABO subtype, H antigen).
  • Intended application (diagnostic assay, transfusion compatibility, transplant monitoring).

Highlights


Expertise in Blood Group Immunology
Creative Biolabs combines decades of immunology expertise with cutting-edge glycan synthesis for precise antigen targeting.

Multipurpose Antibody Formats
We deliver antibodies adaptable to diagnostics, therapeutics, and basic research.

Stringent Quality Standards
Each antibody undergoes comprehensive characterization, ensuring reproducibility and regulatory readiness.

Discover the Creative Biolabs Advantage – Contact Us for a Customized Quote.

Publication

A murine model was generated to reproduce immune responses against type A blood group antigens, providing a platform for therapeutic evaluation. Mice were sensitized through controlled immunization introducing type A-specific determinants, inducing circulating antibodies. Serological assays, including hemagglutination and antigen-binding tests, confirmed antibody activity. Flow cytometry and immunohistochemistry validated selective recognition of type A epitopes with minimal cross-reactivity. This approach demonstrated the feasibility of inducing blood group–specific immunity in animals and established a reliable system for exploring glycan-directed therapies. The model supports investigation of antibody mechanisms and testing strategies that leverage natural blood group antigens in oncology and immunotherapy.

Fig.1 Developing and validating a mouse model for the production of antibodies targeting type A blood group antigens. (OA Literature) Fig.1 Establishment and validation of a mouse model designed to generate antibodies against type A blood group antigens.1

Customer Reviews

Enhanced Transfusion Safety
“Using Creative Biolabs’ anti-blood group antibody development services, we obtained highly specific anti-A antibodies that greatly improved our crossmatch assays.” [Clinical Scientist, Dr. F***]

Reliable Diagnostic Tools
“The custom anti-B antibody developed by Creative Biolabs facilitated consistent ELISA-based detection, reducing variability compared to commercial reagents.” [Researcher, Dr. M***]

Comprehensive Data Support
“Creative Biolabs delivered a validated anti-H antibody package with detailed kinetic and cross-reactivity profiles, streamlining our assay development.” [Lab Director, Dr. R***]

FAQs

Which blood group antigens can you target?

We support development against ABO, H antigen, and other clinically relevant blood group determinants.

Do you provide functional testing, such as complement activation?

Yes, complement-binding and hemolysis assays can be included to evaluate clinical relevance.

How do your services differ from off-the-shelf antibodies?

Our antibodies are custom-developed, thoroughly validated, and optimized for client-specific applications, ensuring superior performance.

Extended Services

Glycoconjugation Services

We provide precise glycoconjugation solutions by coupling glycans to proteins, lipids, or nanoparticles, enabling enhanced immunogenicity, improved detection sensitivity, and versatile applications in vaccine development, diagnostics, and glycan-based research.

Glycoengineering Services

Our glycoengineering services deliver customized modification of glycan structures on cells or proteins using advanced genetic and enzymatic strategies, supporting functional studies, therapeutic antibody optimization, and the creation of novel glycomimetics for translational research.

Creative Biolabs’ Anti-blood group antibody development services integrate expertise in immunohematology, glycobiology, and serology to deliver precise antibody solutions. To explore your project needs and learn how we can support your research, Contact Our Team today.

Reference

  1. Luo, Qiong et al. “ABO blood group antigen therapy: a potential new strategy against solid tumors.” Scientific Reports vol. 11,1 16241. 10 Aug. 2021. Distributed under Open Access license CC BY 4.0, without modification. https://doi.org/10.1038/s41598-021-95794-x
For Research Use Only.

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