Custom antibody generation targeting Lewis A, a type I chain glycan widely studied in transfusion medicine and tumor biomarker research.
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Lewis antigens are carbohydrate determinants in the histo-blood group system and tumor-associated glycans. They are formed through the action of glycosyltransferases such as FUT2 and FUT3, with structural variations influenced by genetic background and secretor status. Clinically, Lewis antigens—including Lewis A, Lewis B, Lewis X, Lewis Y, and their sialylated or modified variants—play critical roles in transfusion medicine, pregnancy serology, oncology, and infectious disease. These glycans are increasingly recognized as valuable biomarkers and therapeutic targets, highlighting the importance of precise and reproducible antibody development.
Are you currently facing challenges with unreliable serological tools, inconsistent glycan-specific detection, or difficulties in developing antibodies against complex carbohydrate antigens? Anti-Lewis antigen antibody development services at Creative Biolabs help you generate highly specific and reliable antibodies through advanced immunogen design, chemoenzymatic glycan synthesis, and validated high-throughput screening platforms.
We offer comprehensive antibody development across the Lewis family of glycans:
Strategies we applied:
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Custom antibody generation targeting Lewis A, a type I chain glycan widely studied in transfusion medicine and tumor biomarker research.
Development of antibodies against Lewis B, supporting clinical serology, host–pathogen interaction studies, and glycan-based diagnostics.
Production of highly specific antibodies recognizing Lewis X, an oncofetal antigen linked to cancer progression and developmental biology.
Antibody design for Lewis Y, a tumor-associated carbohydrate antigen applied in oncology research, diagnostics, and therapeutic development.
Custom antibody services for Lewis M, supporting research into rare blood group variants and transfusion compatibility testing.
Generation of antibodies against Lewis N, providing tools for advanced serological studies and niche clinical research applications.
Creation of antibodies targeting sialyl-Lewis A, a key cancer biomarker involved in metastasis and widely used in oncology diagnostics.
Antibody development for sialyl-Lewis B, enabling research into gastrointestinal cancers and glycan-mediated infection pathways.
Production of antibodies against sialyl-Lewis X, an essential ligand for selectins, supporting studies of inflammation and metastasis.
Generation of antibodies specific to sialyl-Lewis Y, a promising target in cancer immunotherapy and diagnostic development.
Design of antibodies against sialyl-Lewis M, offering specialized tools for rare antigen profiling and comparative glycan analysis.
Custom antibody development for sulfo sialyl-Lewis X, critical in immunology and inflammation research as a selectin-binding glycan.
Production of antibodies recognizing non-fucosylated Lewis X, enabling fine discrimination of glycan modifications in research and diagnostics.
Development of antibodies against fucosyl-Lewis X, supporting tumor biology research and assays for glycan-structure-specific functions.
We design and generate monoclonal, recombinant, and humanized antibodies specifically tailored to Lewis antigens, ensuring optimal specificity and reproducibility.
Our team provides antibody panels with sensitivity to glycan structures and subtle modifications, enabling accurate profiling across diverse applications.
Every antibody is validated across multiple applications such as IHC, IF, WB, and flow cytometry, allowing seamless integration into your workflow.
We supply clients with detailed characterization data, including epitope recognition profiles, binding kinetics, and cross-reactivity analysis, ensuring each antibody performs reliably in complex biological samples.
Define target antigen subtype (e.g., Lewis B, Sialyl-Lewis X) and intended application. Clarify project scope, assay formats, and deliverables to ensure the strategy aligns with client goals.
Generate authentic glycan structures through chemoenzymatic synthesis, with precise control of linkages and modifications. Conjugate to carriers like BSA or KLH, and confirm accuracy using MS or HPLC.
Apply hybridoma or phage display platforms to produce high-affinity antibodies. Screen diverse isotypes and subclones to build a strong candidate pool.
Test candidates with glycan microarrays, ELISA, and inhibition assays to confirm specificity. Cross-check against related glycans to minimize off-target binding.
Refine performance through affinity maturation and isotype engineering, enhancing binding strength, stability, and reproducibility across applications.
Provide datasets covering specificity, sensitivity, kinetics, and cross-reactivity, with recommendations for use in IHC, flow cytometry, or diagnostic ELISA.



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Expanded Biomarker Coverage
“Using Creative Biolabs’ Anti-Sialyl-Lewis A antibody in our oncology research significantly improved tumor progression tracking with high sensitivity.” [Cancer Researcher, Dr. K***]
Reliable Serology Tools
“Creative Biolabs developed a custom Anti-Lewis B antibody that enhanced our transfusion compatibility studies and eliminated inconsistencies seen with commercial reagents.” [Clinical Scientist, Dr. W***]
Unique Epitope Targeting
“The Anti-Sulfo Sialyl-Lewis X antibody from Creative Biolabs enabled our team to explore inflammatory pathways that were previously inaccessible.” [Immunologist, Dr. P***]
We support antibody development for classical Lewis antigens, sialylated derivatives, and modified forms, including sulfo and fucosylated variants.
Yes, our synthesis platforms allow the design of rare immunogens for precise antibody development.
Our antibodies are customized, validated, and optimized for application-specific needs, outperforming generic commercial clones.
We provide tailor-made synthesis of glycans with defined structures, linkages, and degrees of polymerization. Using chemoenzymatic and chemical strategies, we deliver high-purity glycans for use in immunogen preparation, biomarker discovery, and functional studies.
We offer precise glycan modification and labeling, including biotinylation, fluorescent tagging, and carrier conjugation. These services enable sensitive detection, assay integration, and advanced applications such as imaging, glycan arrays, and diagnostic development.
Creative Biolabs’ Anti-Lewis Antigen Antibody Development Services provide precise detection tools for cancer biomarkers, transfusion research, inflammatory disease models, and pathogen adhesion studies. To explore your project needs in detail, Contact Our Team today.