Precision Glycan Library for Breakthrough Discovery
Glycosylation is not just a common post-translational modification that mediates critical biological processes such as cellular signaling, immune regulation, and protein half-life. The inherent complexity of the glycan code is driven by a combinatorial explosion of monosaccharide types, linkages, and branching patterns, which presents a critical barrier to accurate structural assignment. Creative Biolabs' comprehensive suite of glycan libraries provides chemically defined, rigorously validated, and scalable glycan standards. By utilizing our products, you gain the certainty required to satisfy stringent global regulatory demands, accelerate drug target validation, and achieve absolute quantification in the most complex biological matrices. Our unwavering commitment to precision provides the reliable, high-purity standards that translate fundamental glycan discovery into commercial success.
Fig.1 Typical N-glycan structures in different species.1
Product Categories: A Multi-Dimensional View of the Glycome
Our specialized libraries are meticulously categorized to serve distinct analytical and biological applications, providing targeted, high-precision solutions for your most critical projects across biopharma and fundamental research. We understand the breadth and depth of the glycomics field, which is why our product offering is strategically organized into three core pillars. This ensures you access the perfect reagent, whether you are charting new biological pathways or fulfilling rigorous quantification needs.
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Structural and Foundational Libraries
These libraries provide the essential, chemically defined building blocks for fundamental research, structural studies, and enzymatic characterization. They allow researchers to precisely characterize the core biosynthetic machinery and basic biological functions of the glycan chains, often used to define enzyme specificity and reaction kinetics. For foundational studies, our libraries span the core structures:
This is the core resource for biopharma quality control. It provides the full spectrum of complex, high-mannose, and hybrid N-glycan structures, essential for monitoring protein folding, characterizing therapeutic antibodies, and establishing the batch consistency required for submission.
Defining mucin-type glycosylation (Core 1-4), this pivotal library offers structures critical for receptor shielding, cell signaling, and highly specific tumor-associated antigen studies. These standards are indispensable for researchers aiming to resolve the functional differences between closely related mucin core structures and develop novel agents targeting the O-glycome.
This resource is tailored for researchers focused on host-pathogen interactions, blood group determinants, and the core precursors to bioactive human milk oligosaccharides. It ensures precise differentiation between type 1 and type 2 chains, which is fundamental to understanding many enteric pathogen recognition mechanisms.
Crucial for infectious disease research and vaccine development, this library provides highly purified oligomannose structures. These standards are necessary for probing innate immunity receptors and accurately characterizing pathogen recognition. It is also a key tool for congenital disorders of glycosylation (CDG) research.
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Specialized Functional and Antigenic Libraries
These collections focus on highly immunogenic or biologically active structures critical for therapeutic and diagnostic intervention, allowing precise targeting and validation of pathological epitopes that drive disease progression. For targeted therapeutic discovery, we offer highly specialized collections:
This library focuses on key immunogenic tumor-associated antigens (e.g., Tn, sTn) densely presented on mucins (MUC1). These repetitive structures are hallmarks of cancer, making this library an ideal platform for developing next-generation cancer vaccines and T-cell therapies designed to overcome tumor immune evasion.
We provide certified, high-purity synthetic antigens crucial for IVD safety, transfusion medicine research, and infectious disease receptor mapping.
Delivering bioactive glycans specific to infant health, gut microbiome colonization, and neurodevelopment (e.g., 2'-FL, LNnT), this unique library is essential for advanced nutraceutical research and clinical trials. We offer scalable, high-purity synthetic routes, ensuring reliable supply for large-scale product formulation.
Providing defined, size-fractionated oligomers (HS, CS, DS), this library enables precise research into the Extracellular Matrix (ECM), inflammation, and coagulation. These standards are key for designing advanced regenerative medicine scaffolds and studying GAG-protein interactions that regulate growth factors and cell fate.
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Quantitative and Analytical Libraries
These products are chemically modified and certified to maximize analytical performance and precision, decisively solving the most persistent challenges in glycan analysis and quantification. To conquer analytical constraints, our advanced tools ensure data integrity and enhanced sensitivity:
This solution utilizes high-performance fluorescent tags (2-AB, APTS) for optimized hydrophilic interaction liquid chromatography (HILIC-HPLC) and capillary electrophoresis (CE) separation. The APTS tag, specifically, introduces a charge for ultra-high resolution of structural isomers, which is critical for complex quality control environments.
As the mass spectrometry (MS) gold standard, this library provides fully permethylated standards that eliminate signal suppression and improve ionization. This is essential for definitive structural assignment through diagnostic fragment ions and is the key to identifying and characterizing novel or complex glycan structures in low-abundance samples.
Crucial for decoding the pathological sulfation landscape in inflammation and cancer, this library includes C13-labeled standards. These stable isotope standards enable absolute, high-precision quantification in complex clinical samples by serving as internal standards in LC-MS runs.
Specifically tailored for biopharma quality control, this library provides IgG-derived N-glycan standards (e.g., G0F, G1F, G0) certified by HPLC and MS. These are ready-to-use batch release tools, ensuring accurate structural assignment and quantification for all critical quality attributes of therapeutic antibodies.
Why Choose Defined Glycan Standards?
Historically, reliance on naturally sourced glycans (extracted from tissues, fluids, or cell lines) introduces inherent, unacceptable risks that compromise data integrity and delay commercialization. We offer a proven solution to overcome the limitations of natural extraction.
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Batch-to-batch variability and isomeric purity: Natural sources yield heterogeneous mixtures, often containing incomplete or isomerically impure patterns that cannot be fully separated, leading to irreproducible results in sensitive binding and analytical assays. Our proprietary synthetic approach guarantees a single, defined isomer, with controlled linkage and stereochemistry, ensuring unwavering lot consistency and establishing a true gold standard for analytical method development.
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Analytical ambiguity and sensitivity: Native glycans exhibit poor ionization efficiency and complex fragmentation patterns, and positional isomers are notoriously difficult to separate, complicating mass spectrometry (MS) and HPLC analysis of low-abundance biological samples. We provide chemically derivatized and certified standards optimized for maximum performance, enhancing signal-to-noise ratios and enabling unambiguous structural assignment and reliable quantification.
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Biohazard risk: Antigens derived from human or animal sources carry inherent biohazard risks and require extensive, costly screening for adventitious agents. Our synthetic standards bypass these risks, providing clean, traceable materials with full documentation essential for IVD kit manufacturing and vaccine development.
Customization and Scalability: Your Partner in Translation
We are your comprehensive technical partner, supporting projects from exploratory research to commercial production, ensuring a smooth transition across all phases of development:
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Bulk supply and scalability: Our state-of-the-art facilities have the capacity to scale production from analytical microgram standards to multi-kilogram quantities of high-demand structures, essential for advanced nutraceutical formulation and IVD manufacturing.
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Custom synthesis services: Our expert glycochemists specialize in de novo synthesis of unique, complex, or challenging glycan structures, non-standard linkages, and customized isotopic or affinity labeling to meet your precise molecular specifications.
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Integrated technical support: Gain access to professional Ph.D.-level technical consultation on assay development, MS method optimization, and seamless integration of our standards into your established analytical platforms, ensuring rapid project startup and troubleshooting support.
Initiate Your Precision Glycomics Project Today
Stop struggling with batch variability, analytical challenges, and unreliable biological sources. Partner with the Creative Biolab on defined glycan standards. Incorporate our certified glycan libraries into your workflow to ensure the quality, confidence, and speed required for your next breakthrough. Request a personalized quotation now to define your research with absolute precision.
Reference
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Zhao, Xiaoya et al. "Recent Chemical and Chemoenzymatic Strategies to Complex-Type N-Glycans." Frontiers in Chemistry Vol 10 880128. 26 May. 2022. Distributed under an Open Access license CC BY 4.0, without modification. https://doi.org/10.3389/fchem.2022.880128
