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Lacto Glycan Library Products

Research Tracks Powered by the Lacto Glycan Library (LGL)

Lacto-glycans (LGs) are core carbohydrate structures built upon the fundamental lactose disaccharide. Found ubiquitously across mammalian systems, these molecules are sophisticated, dynamic messengers that define the cell surface landscape and dictate fundamental biological outcomes across various physiological contexts. Unlike genetic codes, the glycan code is defined by combinatorial complexity - variations in monosaccharide units, linkage positions (β-1-3 vs. β-1-4), anomeric configurations (α vs. β), and branching patterns. The precise stereochemistry of a lacto-glycan is a command to a cell or pathogen. Access to a structurally pure and extensively characterized Glycan Library, such as the LGL, N-Glycan, HMO-Glycan, and Tag based Glycan, is the critical prerequisite for translating these commands into breakthrough therapeutics, advanced nutritional products, and diagnostics.

(Creative Biolabs AI)

Developmental biology

  • Lacto-glycans are essential precursors for complex glycosphingolipids and function as crucial ligands in processes like axon guidance and synaptic plasticity, being critical for myelination and cognitive maturation.

(Creative Biolabs AI)

Precision immunology

  • Lacto-glycans act as high-affinity decoy receptors, competitively inhibiting the binding of lectins, viruses, and bacterial toxins to host cell surfaces. They also directly influence T-cell differentiation and immune regulation. Our library guarantees the essential linkage specificity, providing pure α-1-2, α-1-3, or α-1-4 fucosylation linkages, which are crucial for accurate binding assays.

(Creative Biolabs AI)

Gut microbiome science

  • Lacto-glycans serve as highly selective, non-digestible substrates, uniquely fostering the proliferation and functional activity of key beneficial gut microflora strains (e.g., Bifidobacterium). For commercial and large-scale academic research, we address the critical need for high-volume supply, providing reliable, multi-kilogram quantities of difficult-to-synthesize core structures for large-scale fermentation studies.

(Creative Biolabs AI)

Cancer glycobiology

  • Alterations in lacto-series structures (e.g., expression of specific Lewis antigens) often mark stages of malignancy and metastasis, serving as crucial diagnostic and prognostic markers. The LGL ensures epitope fidelity by supplying complex branched and multi-fucosylated structures, allowing for the precise mapping of antibody binding specificity in oncology. Access to these pure markers enables researchers to develop novel glycan-based diagnostic methods and targeted drug delivery systems that specifically exploit tumor-specific glycan profiles.

Structural Diversity

Our LGL is a comprehensive map of the lacto-glycome, essential for dissecting the subtlety of biological recognition. The structures below showcase the range of chemical backbones and terminal residues available, allowing you to specifically target and validate distinct biological pathways.

Type 1 Core Series

Gal-β-1-3-GlcNAc extension from the lactose core. Found in the core of structures like LNT and Lewis a/b antigens.

Type 2 Core Series

Gal-β-1-4-GlcNAc extension from the lactose core. Found in the core of structures like LNnT and Lewis x/y antigens.

Service Features

Fucosylated Series

Contains fucose (α-1-2, α-1-3, or α-1-4 linkage) at the non-reducing end.

Sialylated Series

Contains N-acetylneuraminic acid (Neu5Ac) in α-2-3 or α-2-6 linkages.

Our collection guarantees the isolation of pure isomers, allowing researchers to distinguish the functional differences between closely related structures (e.g., LNT vs. LNnT), which can determine specific receptor binding affinity and biological outcome.

Common Lacto Glycan Structures
CAT#: GLJF-1125-HX499 CAT#: GLJF-1125-HX500 CAT#: GLJF-1125-HX501
CAT#: GLJF-1125-HX502 CAT#: GLJF-1125-HX503 CAT#: GLJF-1125-HX504
CAT#: GLJF-1125-HX505 CAT#: GLJF-1125-HX506 CAT#: GLJF-1125-HX507
CAT#: GLJF-1125-HX508 CAT#: GLJF-1125-HX509 CAT#: GLJF-1125-HX510
CAT#: GLJF-1125-HX511 CAT#: GLJF-1125-HX512 CAT#: GLJF-1125-HX513
CAT#: GLJF-1125-HX514 CAT#: GLJF-1125-HX515 CAT#: GLJF-1125-HX516

For more structures, please refer to our Lacto Glycan Library Catalog.

Comprehensive LGL Solution

The natural isolation of lacto-glycans is fraught with challenges - low yields, extreme structural heterogeneity, and the near-impossibility of complete isomer separation. Our LGL is engineered to circumvent these limitations through a robust, proprietary chemo-enzymatic synthesis platform.

  • Synthesis & Purity Assurance: Products are derived from controlled enzymatic reactions, followed by advanced preparative chromatography. Purity greater than 95% guaranteed via quantitative HPLC and confirmed by multi-dimensional spectroscopy.
  • Structural Breadth: Our library provides various unique lacto-series structures, meticulously spanning Type 1 (Lac-N-tetraose, Gal-β-1-3-GlcNAc) and Type 2 (Lac-N-neotetraose, Gal-β-1-4-GlcNAc) core backbones, including critical fucosylated, sialylated, and sulfated modifications.
  • Scalability & Supply Chain: We offer seamless transition from analytical microgram standards to multi-kilogram quantities. Our global supply chain ensures dependable, high-capacity access with guaranteed batch-to-batch consistency.

The LGL is designed as a modular system, providing versatile reagents that integrate seamlessly into any advanced glycomics laboratory.

Purified Lacto Glycan Standards

These high-purity, fully validated standards are the necessary benchmark for establishing robust analytical methods and functional assays. Key products include neutral oligosaccharides (LNT, LNnT, LNH), acidic/sialylated oligosaccharides (LST-a, LST-b), and fucosylated antigens (Lewis antigens, 2'-FL, 3-FL).

Custom Glycan Arrays

We offer custom-printed microarrays for the analysis of your specific binding partners (antibodies, lectins, viral capsids), which can accelerate the identification and characterization of glycan-protein interactions.

Conjugated Lacto-Glycans

LGs conjugated to high-molecular-weight carriers like KLH or BSA using optimized N-linkers (amide bonds) for generating highly specific monoclonal or polyclonal antibodies with defined, stable epitopes. Biotinylated LGs for robust, high-sensitivity detection in surface plasmon resonance (SPR), competitive inhibition assay experiments.

Bulk Synthesis & Custom Structures

Beyond our catalogue, our capacity for proprietary chemical and enzymatic synthesis makes us your essential partner for cutting-edge projects requiring non-standard structures or large volumes. Initiate a detailed consultation with our Ph.D. synthetic chemists to define your precise target structure, desired quantity, and receive a guaranteed synthesis timeline and proprietary confidentiality agreement.

How to Contact Us

The complexity of biology demands the simplicity of perfect reagents. Leverage the Creative Biolabs' unparalleled quality, technical rigor, and synthesis capacity to source the high-purity lacto-glycans that will robustly validate your next major hypothesis and drive your project toward commercial success. Please contact our polysaccharide experts to inquire about product information.

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