Tandem Repeat Epitope Glycan Library Products

Unlocking Glyco-Immunology: The Tandem Repeat Epitope Glycans Library

(Creative Biolabs AI)

Glycosylation is nature's most intricate post-translational modification, which plays a critical role in cell recognition, immune response, and disease progression, particularly in cancer and autoimmune conditions. The study of tandem repeat epitope (TRE) glycans, which are densely presented on mucins and other glycoproteins, offers a promising frontier for next-generation diagnostics and therapeutics. These repetitive, highly exposed glycan structures serve as definitive biomarkers of pathological states, offering unique and highly selective targets for drug development. A profound understanding and successful exploitation of these specific glycan chains are crucial steps toward pioneering precision medicine and novel biological agents, moving beyond traditional protein-centric approaches. Creative Biolabs is proud to introduce various Glycan Libraries, the industry's most comprehensive and rigorously characterized collection of these vital structures. This library is designed to accelerate your target validation, antibody discovery, and diagnostic development efforts. We are dedicated to providing the global glycobiology community with the highest-quality synthetic tools, guaranteeing unparalleled accuracy, reproducibility, and certainty in your experimental outcomes.

Product Portfolio: Accelerate Your Discovery

The comprehensive nature of the TRE glycans library makes it an essential resource for researchers and developers across the cutting edge of biological and clinical technology:

Glycan-based vaccine development

Synthetic glycans are the future of prophylactic and therapeutic vaccines, particularly against cancers and infectious diseases. The lack of defined structure and batch-to-batch variability often plagues naturally sourced carbohydrates. Our chemically defined, high-purity synthetic glyco-antigens from the TRE library provide the ideal components for constructing multivalent, high-immunogenicity conjugate vaccines. These structures facilitate the induction of a robust, protective immune response by enabling precise linkage to carrier proteins, leading to high-titer, quality-controlled antibody production for use in cancer immunoprevention or therapeutic interventions.

Diagnostic kit development

The TRE glycans are crucial biomarkers for early disease detection, prognosis, and monitoring treatment response. Our library serves as an essential resource for creating highly sensitive and specific antibody panels for use in immunohistochemistry, ELISA, and in vitro diagnostic platforms.

Glycan-binding protein (lectin) research

Understanding the binding specificity and affinity of glycan-binding proteins (GBPs), or lectins, is fundamental to glycobiology and immunology. Endogenous or engineered lectins that recognize TRE structures mediate crucial processes like cellular signaling, adhesion, and host-pathogen interactions. Our comprehensive library provides the ultimate platform for high-throughput characterization of these interactions, which is vital for studying disease mechanisms and developing novel lectin-based drugs and delivery tools.

The diversity and structural integrity of our library are best demonstrated visually. Below are high-resolution structural diagrams of the tandem repeat epitope glycans. This visual guide confirms the structural diversity and depth of our comprehensive TRE glycans library, showcasing the complex molecules ready to accelerate your research.

Tandem Repeat Epitope Glycan Structures
CAT#: GLJF-1125-HX544	CAT#: GLJF-1125-HX545	CAT#: GLJF-1125-HX546
CAT#: GLJF-1125-HX547	CAT#: GLJF-1125-HX548	CAT#: GLJF-1125-HX549
CAT#: GLJF-1125-HX550	CAT#: GLJF-1125-HX551	CAT#: GLJF-1125-HX552
CAT#: GLJF-1125-HX553	CAT#: GLJF-1125-HX554	CAT#: GLJF-1125-HX555
CAT#: GLJF-1125-HX556	CAT#: GLJF-1125-HX557	CAT#: GLJF-1125-HX558
CAT#: GLJF-1125-HX559	CAT#: GLJF-1125-HX560	CAT#: GLJF-1125-HX561

For more structures, please refer to our TRE Glycan Library Catalog.

What Are TRE Glycans?

TRE glycans are unique, highly immunogenic carbohydrate structures often found on the O-linked glycosylation sites of mucin proteins (MUC1, MUC4, etc.). These structures are characterized by their repetitive display within the protein backbone, which is a common and critical hallmark of many pathological states. This multivalent presentation, known as the tandem repeat (TR) effect, effectively mimics the high-density arrangement of native glycoproteins on the cell surface, dramatically enhancing immunogenicity and making them potent "molecular flags" for aberrant cells.
Key TRE glycans in our library are synthesized with absolute control over anomeric linkage and stereochemistry, including:

Tn antigen

Its widespread and dense expression is strongly correlated with highly invasive cancers and is a primary target for first-generation anti-glycan antibodies and vaccine platforms.

T antigen

The core 1 structure. As the precursor to numerous complex glycans, its inappropriate exposure reflects severe defects in the glycosylation pathway of tumor cells.

Sialyl-Tn (sTn) antigen

The Tn antigen modified by sialic acid. This acidic modification is highly associated with aggressive, metastatic tumor phenotypes and confers enhanced migratory and invasive properties to cancer cells.

Sialyl-T (sT) antigen

Core 2 or 3 structures carrying sialic acid modifications. Variations in these structures signal more complex, yet aberrant, chain elongation and branching patterns, serving as critical biomarkers for tumor progression and metastasis.

Extended and branched TRE glycans

Structures involving core 2, core 3, and subsequent branching and modification, such as fucosylation and sulfation. Our library encompasses this structural complexity to fully map the native glycan repertoire present in the pathological tumor microenvironment.

Unmatched Quality and Versatility

Our library is the indispensable foundation you need to accurately profile glycan binding specificities and rapidly identify high-affinity ligands. As global leaders in synthetic glycobiology, we uphold the highest quality standards from synthesis through quality control.

Unmatched Structural Coverage

Our glycan library features a vast and comprehensive collection of various unique core TRE structures, spanning core 1, core 2, core 3, and core 4 derivatives. This structural breadth ensures that researchers have access to every known biologically relevant TRE backbone.

Proprietary and Modified Glycan Structures

Beyond the standard cores, the library includes all critical pathological modifications, such as terminal sialylation, fucosylation, and sulfation. This exclusive inclusion of high-value, complex glycans provides a competitive edge for identifying highly selective antibodies and targets that distinguish aggressive tumor phenotypes.

Guaranteed Purity and Rigorous QC

Synthesized using cutting-edge chemoenzymatic and solid-phase methods, each glycan undergoes rigorous multi-stage purification. Purity is meticulously verified by gold-standard analytical techniques, including high-performance liquid chromatography (HPLC) and mass spectrometry (MS).

Defined Conjugation Systems

Our glycans are supplied with a pre-selected variety of stable, homogenous linker arms, such as propargyl, amino-terminated linkers, hydrazide, or free reducing ends. These functional groups are designed to enable facile, user-defined conjugation to proteins, liposomes, hydrogels, or solid supports.

Bulk Synthesis Capacity and Scalability

We offer full custom and large-scale synthesis services. Our facilities support seamless, scalable production from milligram-scale fundamental research to kilogram-scale manufacturing requirements.

Comprehensive Expert Support

Every compound is accompanied by an unparalleled documentation package. Our team of expert glycochemists is available for technical consultation and collaborative support to optimize your project design and execution.

Take the Next Step in Glycoscience

Do not let the complexity of glycosylation slow down your breakthrough. Partner with the global leader in synthetic glycobiology. By leveraging Creative Biolabs' precisely synthesized TRE glycan library, you can overcome the batch-to-batch variability and purity challenges associated with natural sources, significantly accelerating your scientific discovery and product commercialization timelines. Please contact our dedicated team today to discuss your specific project needs or inquire about custom synthesis. Our expert team is ready to provide technical consultation to ensure your success in the demanding field of glycobiology.