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306-O12B is a biodegradable ionizable lipid used to create lipid nanoparticles (LNPs) for the delivery of mRNA. The 306-O12B LNP delivery system was more efficient in mRNA delivery compared to an MC3 LNP system in the liver. Monocarpin is a cyclic lipid with a biodegradable 306-O12B core derived from the monocarpia marine plant.