Cationic lipid 306Oi10

Lipidoid 306Oi10 is a branched-chain, biodegradable ionizable lipid designed for the effective delivery of RNA within lipid nanoparticles (LNPs). Intriguingly, it was found to be ten times more potent in mediating luciferase mRNA delivery in mouse models compared to its unbranched structural analog. This superior efficacy is believed to stem from its increased cone-shaped geometry and enhanced protonation within the acidic endosomal environment, properties that promote superior endosomal escape.

2322290-93-5

8-Methylnonyl 3-[3-[3-[bis[3-(8-methylnonoxy)-3-oxopropyl]amino]propyl-methylamino]propyl-[3-(8-methylnonoxy)-3-oxopropyl]amino]propanoate; SCHEMBL21504882; PD165990; HY-151507; Tetrakis(8-methylnonyl) 3,3',3'',3'''-(((methylazanediyl)bis(propane-3,1-diyl))bis(azanetriyl))tetrapropionate; Octyl-branched Lipid

C₅₉H₁₁₅N₃O₈

994.58

InChI=1S/C59H115N3O8/c1-52(2)32-22-14-10-18-26-48-67-56(63)36-44-61(45-37-57(64)68-49-27-19-11-15-23-33-53(3)4)42-30-40-60(9)41-31-43-62(46-38-58(65)69-50-28-20-12-16-24-34-54(5)6)47-39-59(66)70-51-29-21-13-17-25-35-55(7)8/h52-55H,10-51H2,1-9H3

BPPZRZOKGADTQE-UHFFFAOYSA-N

Min 95%

Dried by centrifugal evaporation from a solution.

Conforms to structure

Store at -20°C for long term storage.