Cationic lipid OA2

Cationic lipid OA2 is an ionizable lipid specifically developed for the preparation of lipid nanoparticles (LNPs) for gene silencing applications. It is structurally similar to lipids like LipofectamineTM, and its LNP formulations are capable of delivering short interfering RNA (siRNA) payloads. OA2 LNPs were shown to successfully deliver siRNA to downregulate cytokine signaling 1 (SOCS1) in mouse bone marrow dendritic cells, resulting in a measurable reduction of tumor size in a B16-OVA mouse melanoma model.

1401620-16-3

Di((Z)-octadec-9-en-1-yl) L-lysyl-L-glutamate, hydrochloride salt; Dioleoyl L-lysyl-L-glutamate; Dioleoyl Lys-Glu; Bis[(Z)-octadec-9-enyl] (2S)-2-[[(2S)-2,6-diaminohexanoyl]amino]pentanedioate; Dioleyl-N-(l-lysyl)-l-glutamate

C₄₇H₉₁Cl₂N₃O₅

849.16

InChI=1S/C47H89N3O5/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-35-41-54-45(51)39-38-44(50-46(52)43(49)37-33-34-40-48)47(53)55-42-36-32-30-28-26-24-22-20-18-16-14-12-10-8-6-4-2/h17-20,43-44H,3-16,21-42,48-49H2,1-2H3,(H,50,52)/b19-17-,20-18-/t43-,44-/m0/s1

QKDTWVZLMXVUPK-JCOZVHEOSA-N

Min 95%

Dried by centrifugal evaporation from a solution.

Conforms to structure

Store at -20°C for long term storage.