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A synthetic, short-chain (diC8) analog of the plasma membrane phosphoinositide, Phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), incorporating a fluorovinylphosphate moiety. PI(4,5)P2 is a critical lipid messenger that controls numerous processes, including membrane excitability and cytoskeletal organization. The short acyl chains enhance its solubility, making it highly suitable for assays where rapid, homogeneous delivery of the lipid into an aqueous environment is necessary.