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GlycoErase™ ALG12 Knockout Human Kidney Clear Cell Carcinoma Cell 786-O

CAT#: GLJF-0525-JF514

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Overview Specification Target Information Related Products
Overview
Description
The ALG12 knockout human kidney clear cell carcinoma cell 786-O line represents a valuable tool for elucidating the consequences of N-glycosylation disruption in the context of renal carcinoma, where the lack of ALG12 impairs N-glycan assembly, thereby allowing investigators to examine the effects of such glycosylation defects on tumor progression, interactions with the surrounding microenvironment, resistance to chemotherapeutic agents, and the rational design of targeted interventions.
Product Type
KO Cell Lines
Species
Human
Cell Morphology
Epithelial-like, adherent
Passage Ratio
1:2~1:4
Cell Line
786-O
Primary Disease
Renal Cell Carcinoma
Lineage
Kidney
Specification
Cell Viability
>90%
Sterility Test
The sterility test indicated an absence of microbial growth.
Identity Test
STR identification
Mycoplasma Test
Negative
Virus Test
Negative for HIV, HBV and HCV.
Genetic Stability Testing
We conduct cell genetic stability studies in full compliance with ICH guidelines. Our expertise enables us to design and execute a comprehensive testing program tailored to your specific needs and regulatory requirements.
Validation
PCR, Sanger Sequencing
Culture Medium
FBS & RPMI
Application
Functional assay
Size
1 M cells/vial*2
Product Format
Frozen
Shipping
Dry ice
Availability Status
Made to order
Handling Notes
Upon receipt, this product must be immediately transferred from dry ice to liquid nitrogen (-150°C to -190°C) and stored in a liquid nitrogen tank. Cell viability is critically dependent on proper handling. We cannot guarantee viability if these instructions are not strictly adhered to.
Product Disclaimer
This product is provided for research only, not suitable for human or animal use. Due to the inherent limitations of infectious agent testing, investigators must exercise extreme caution when handling cells provided by Creative Biolabs, treating all cells as potentially biohazardous.
Target Information
Target
ALG12
Full Name
ALG12 alpha-1,6-mannosyltransferase
Alternative Name
ECM39, CDG1G
Location
22q13.33
Gene ID
79087
Summary
This gene encodes a protein that belongs to the glycosyltransferase 22 family. The protein plays a crucial role in protein glycosylation by catalyzing the addition of the eighth mannose residue to the dolichol pyrophosphate-linked oligosaccharide precursor (dolichol-PP-Man₇GlcNAc₂). This addition occurs via an alpha-1,6 linkage, and is essential for the proper assembly of the oligosaccharide chain required for N-linked glycoprotein synthesis.
For Research Use Only.
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