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GlycoErase™ ALG3 Knockout Human Lung Cancer Cell A-427

CAT#: GLJF-0525-JF1283

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Overview Specification Target Information Related Products
Overview
Description
The ALG3 knockout A-427 cell line represents a pivotal tool for unraveling the importance of early-stage N-glycosylation events in lung adenocarcinoma, as the deficiency in ALG3 results in aberrant N-glycan structures, thereby facilitating the investigation of how these anomalies influence malignant cell behavior, contribute to chemoresistance, and serve as potential sources for identifying clinically relevant biomarkers and therapeutic strategies aimed at glycosylation defects.
Product Type
KO Cell Lines
Species
Human
Cell Morphology
Epithelial-like, adherent
Passage Ratio
1:2~1:3
Cell Line
A-427
Primary Disease
Non-Small Cell Lung Cancer
Lineage
Lung
Specification
Cell Viability
>90%
Sterility Test
The sterility test indicated an absence of microbial growth.
Identity Test
STR identification
Mycoplasma Test
Negative
Virus Test
Negative for HIV, HBV and HCV.
Genetic Stability Testing
We conduct cell genetic stability studies in full compliance with ICH guidelines. Our expertise enables us to design and execute a comprehensive testing program tailored to your specific needs and regulatory requirements.
Validation
PCR, Sanger Sequencing
Culture Medium
FBS & RPMI
Application
Functional assay
Size
1 M cells/vial*2
Product Format
Frozen
Shipping
Dry ice
Availability Status
Made to order
Handling Notes
Upon receipt, this product must be immediately transferred from dry ice to liquid nitrogen (-150°C to -190°C) and stored in a liquid nitrogen tank. Cell viability is critically dependent on proper handling. We cannot guarantee viability if these instructions are not strictly adhered to.
Product Disclaimer
This product is provided for research only, not suitable for human or animal use. Due to the inherent limitations of infectious agent testing, investigators must exercise extreme caution when handling cells provided by Creative Biolabs, treating all cells as potentially biohazardous.
Target Information
Target
ALG3
Full Name
ALG3 alpha-1,3- mannosyltransferase
Alternative Name
NOT56L, D16Ertd36e, CDGS4, Not56
Location
3q27.1
Gene ID
10195
Summary
Key player in N-glycosylation, adding alpha 1,3 mannose (dol-P-Man to Man5GlcNAc2-PP-Dol); disruptions linked to CDG-Id (congenital disorder of glycosylation type Id), causing abnormal N-glycosylation and potential neurological issues.
For Research Use Only.
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