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GlycoErase™ ALG6 Knockout Human Osteosarcoma Cell 143B

CAT#: GLJF-0525-JF133

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Overview Specification Target Information Related Products
Overview
Description
The ALG6 knockout 143B cell line proves effective for investigating the initiation of N-glycosylation; the absence of ALG6 impairs early N-glycosylation steps, potentially leading to protein misfolding, thus allowing researchers to study the roles of N-glycosylation disorders in bone sarcoma cell proliferation, migration, drug responsiveness, and to devise drugs targeting specific pathway components.
Product Type
KO Cell Lines
Species
Human
Cell Morphology
Epithelial-like, adherent
Passage Ratio
1:2~1:3
Cell Line
143B
Primary Disease
Osteosarcoma
Lineage
Bone
Specification
Cell Viability
>90%
Sterility Test
The sterility test indicated an absence of microbial growth.
Identity Test
STR identification
Mycoplasma Test
Negative
Virus Test
Negative for HIV, HBV and HCV.
Genetic Stability Testing
We conduct cell genetic stability studies in full compliance with ICH guidelines. Our expertise enables us to design and execute a comprehensive testing program tailored to your specific needs and regulatory requirements.
Validation
PCR, Sanger Sequencing
Culture Medium
Bromodeoxyuridine & EMEM & FBS & Glutamine
Application
Functional assay
Size
1 M cells/vial*2
Product Format
Frozen
Shipping
Dry ice
Availability Status
Made to order
Handling Notes
Upon receipt, this product must be immediately transferred from dry ice to liquid nitrogen (-150°C to -190°C) and stored in a liquid nitrogen tank. Cell viability is critically dependent on proper handling. We cannot guarantee viability if these instructions are not strictly adhered to.
Product Disclaimer
This product is provided for research only, not suitable for human or animal use. Due to the inherent limitations of infectious agent testing, investigators must exercise extreme caution when handling cells provided by Creative Biolabs, treating all cells as potentially biohazardous.
Target Information
Target
ALG6
Full Name
ALG6 alpha-1,3-glucosyltransferase
Alternative Name
CDG1C
Location
1p31.3
Gene ID
29929
Summary
Catalyzes the first glucose addition to the lipid-linked oligosaccharide precursor in N-linked glycosylation; a critical early step in this essential protein modification process.
For Research Use Only.
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