GlycoErase™ ALG6 Knockout Human Bladder Cancer Cell 5637 (CAT#: GLJF-0525-JF5)

Description	Genetically modified human bladder bancer bell 5637 lines with disrupted ALG6 expression serve as a compelling model to dissect the initiation phase of N-glycosylation, where the induced ALG6 deficiency leads to compromised early-stage N-glycan processing, potentially triggering protein misfolding and cellular dysfunction; consequently, investigators utilize this cellular system to probe the involvement of N-glycosylation defects in the context of bladder cancer cell proliferation, motility, drug sensitivity, and for the rational design of therapeutic agents targeting these pathways.
Product Type	KO Cell Lines
Species	Human
Cell Morphology	Epithelial-like, adherent
Passage Ratio	1:3~1:6
Cell Line	5637
Primary Disease	Bladder Urothelial Carcinoma
Lineage	Bladder/Urinary Tract

Cell Viability	>90%
Sterility Test	The sterility test indicated an absence of microbial growth.
Identity Test	STR identification
Mycoplasma Test	Negative
Virus Test	Negative for HIV, HBV and HCV.
Genetic Stability Testing	We conduct cell genetic stability studies in full compliance with ICH guidelines. Our expertise enables us to design and execute a comprehensive testing program tailored to your specific needs and regulatory requirements.
Validation	PCR, Sanger Sequencing
Culture Medium	FBS & Penicillin/Streptomycin & RPMI
Application	Functional assay
Size	1 M cells/vial*2
Product Format	Frozen
Shipping	Dry ice
Availability Status	Made to order
Handling Notes	Upon receipt, this product must be immediately transferred from dry ice to liquid nitrogen (-150°C to -190°C) and stored in a liquid nitrogen tank. Cell viability is critically dependent on proper handling. We cannot guarantee viability if these instructions are not strictly adhered to.
Product Disclaimer	This product is provided for research only, not suitable for human or animal use. Due to the inherent limitations of infectious agent testing, investigators must exercise extreme caution when handling cells provided by Creative Biolabs, treating all cells as potentially biohazardous.

Target	ALG6
Full Name	ALG6 alpha-1,3-glucosyltransferase
Alternative Name	CDG1C
Location	1p31.3
Gene ID	29929
Summary	Catalyzes the first glucose addition to the lipid-linked oligosaccharide precursor in N-linked glycosylation; a critical early step in this essential protein modification process.