GlycoErase™ ALG6 Knockout Human Bladder Cancer Cell 5637

Genetically modified human bladder bancer bell 5637 lines with disrupted ALG6 expression serve as a compelling model to dissect the initiation phase of N-glycosylation, where the induced ALG6 deficiency leads to compromised early-stage N-glycan processing, potentially triggering protein misfolding and cellular dysfunction; consequently, investigators utilize this cellular system to probe the involvement of N-glycosylation defects in the context of bladder cancer cell proliferation, motility, drug sensitivity, and for the rational design of therapeutic agents targeting these pathways.

KO Cell Lines

Human

Epithelial-like, adherent

1:3~1:6

5637

Bladder Urothelial Carcinoma

Bladder/Urinary Tract

>90%

The sterility test indicated an absence of microbial growth.

STR identification

Negative

Negative for HIV, HBV and HCV.

We conduct cell genetic stability studies in full compliance with ICH guidelines. Our expertise enables us to design and execute a comprehensive testing program tailored to your specific needs and regulatory requirements.

PCR, Sanger Sequencing

FBS & Penicillin/Streptomycin & RPMI

Functional assay

1 M cells/vial*2

Frozen

Dry ice

Made to order

Upon receipt, this product must be immediately transferred from dry ice to liquid nitrogen (-150°C to -190°C) and stored in a liquid nitrogen tank. Cell viability is critically dependent on proper handling. We cannot guarantee viability if these instructions are not strictly adhered to.

This product is provided for research only, not suitable for human or animal use. Due to the inherent limitations of infectious agent testing, investigators must exercise extreme caution when handling cells provided by Creative Biolabs, treating all cells as potentially biohazardous.

ALG6

ALG6 alpha-1,3-glucosyltransferase

CDG1C

1p31.3

Catalyzes the first glucose addition to the lipid-linked oligosaccharide precursor in N-linked glycosylation; a critical early step in this essential protein modification process.