GlycoErase™ ALG9 Knockout Human Renal Cell Adenocarcinoma Cell 769-P (CAT#: GLJF-0525-JF390)

Description	The ALG9 deficient human renal cell adenocarcinoma cell 769-P line is a valuable resource for assessing defects in lipid-linked oligosaccharide assembly within the context of renal cell adenocarcinoma, as ALG9 deficiency disrupts the N-glycosylation pathway, thereby allowing researchers to examine the correlations between N-glycosylation abnormalities and the initiation, progression, and metastatic spread of renal carcinoma, as well as to explore therapeutic avenues targeting ALG9 function.
Product Type	KO Cell Lines
Species	Human
Cell Morphology	Epithelial-like, adherent
Passage Ratio	1:4~1:12
Cell Line	769-P
Primary Disease	Renal Cell Carcinoma
Lineage	Kidney

Cell Viability	>90%
Sterility Test	The sterility test indicated an absence of microbial growth.
Identity Test	STR identification
Mycoplasma Test	Negative
Virus Test	Negative for HIV, HBV and HCV.
Genetic Stability Testing	We conduct cell genetic stability studies in full compliance with ICH guidelines. Our expertise enables us to design and execute a comprehensive testing program tailored to your specific needs and regulatory requirements.
Validation	PCR, Sanger Sequencing
Culture Medium	Glutamine & NaHCO₃ & RPMI
Application	Functional assay
Size	1 M cells/vial*2
Product Format	Frozen
Shipping	Dry ice
Availability Status	Made to order
Handling Notes	Upon receipt, this product must be immediately transferred from dry ice to liquid nitrogen (-150°C to -190°C) and stored in a liquid nitrogen tank. Cell viability is critically dependent on proper handling. We cannot guarantee viability if these instructions are not strictly adhered to.
Product Disclaimer	This product is provided for research only, not suitable for human or animal use. Due to the inherent limitations of infectious agent testing, investigators must exercise extreme caution when handling cells provided by Creative Biolabs, treating all cells as potentially biohazardous.

Target	ALG9
Full Name	ALG9 alpha-1,2-mannosyltransferase
Alternative Name	DIBD1
Location	11q23.1
Gene ID	79796
Summary	Facilitates lipid-linked oligosaccharide assembly; mutations lead to CDG II (congenital disorder of glycosylation type II); multiple transcript variants (different isoforms) may influence enzyme specificity.