GlycoErase™ ALG9 Knockout Human Ovarian Cancer Cell A2780 (CAT#: GLJF-0525-JF1030)

Description	The ALG9 deficient A2780 cell line provides a valuable tool for evaluating defects in lipid-linked oligosaccharide assembly, a critical step in N-glycosylation, within the context of ovarian cancer, enabling the exploration of the relationship between N-glycosylation abnormalities and ovarian tumor development, progression, metastasis, and the potential of ALG9 as a therapeutic target.
Product Type	KO Cell Lines
Species	Human
Cell Morphology	Epithelial-like, adherent
Passage Ratio	1:3~1:6
Cell Line	A2780
Primary Disease	Ovarian Epithelial Tumor
Lineage	Ovary/Fallopian Tube

Cell Viability	>90%
Sterility Test	The sterility test indicated an absence of microbial growth.
Identity Test	STR identification
Mycoplasma Test	Negative
Virus Test	Negative for HIV, HBV and HCV.
Genetic Stability Testing	We conduct cell genetic stability studies in full compliance with ICH guidelines. Our expertise enables us to design and execute a comprehensive testing program tailored to your specific needs and regulatory requirements.
Validation	PCR, Sanger Sequencing
Culture Medium	FBS & Glutamine & RPMI
Application	Functional assay
Size	1 M cells/vial*2
Product Format	Frozen
Shipping	Dry ice
Availability Status	Made to order
Handling Notes	Upon receipt, this product must be immediately transferred from dry ice to liquid nitrogen (-150°C to -190°C) and stored in a liquid nitrogen tank. Cell viability is critically dependent on proper handling. We cannot guarantee viability if these instructions are not strictly adhered to.
Product Disclaimer	This product is provided for research only, not suitable for human or animal use. Due to the inherent limitations of infectious agent testing, investigators must exercise extreme caution when handling cells provided by Creative Biolabs, treating all cells as potentially biohazardous.

Target	ALG9
Full Name	ALG9 alpha-1,2-mannosyltransferase
Alternative Name	DIBD1
Location	11q23.1
Gene ID	79796
Summary	Facilitates lipid-linked oligosaccharide assembly; mutations lead to CDG II (congenital disorder of glycosylation type II); multiple transcript variants (different isoforms) may influence enzyme specificity.