GlycoErase™ AVPR1A Knockout CHO-K1 Cell Line (CAT#: GLJF-0825-JF269)

Description	GlycoErase™ AVPR1A knockout CHO-K1 cell line is a CHO-K1 model in which AVPR1A expression has been deleted. AVPR1A encodes a G protein-coupled receptor for arginine vasopressin, mediating downstream phosphatidylinositol-calcium signaling that regulates vascular contraction, platelet aggregation, glycogenolysis, and cell proliferation. The knockout of AVPR1A in the CHO-K1 background offers a specialized system for studying GPCR signaling, vasopressin receptor biology, and calcium-dependent cellular responses, and supports applications in cardiovascular research, platelet function studies, and therapeutic discovery.
Product Type	KO Cell Lines
Species	Hamster
Cell Morphology	Epithelial, adherent
Passage Ratio	1:3~1:5
Cell Line	CHO-K1
Lineage	Chinese hamster ovary

Cell Viability	>90%
Sterility Test	The sterility test indicated an absence of microbial growth.
Identity Test	STR identification
Mycoplasma Test	Negative
Virus Test	Negative for HIV, HBV and HCV.
Genetic Stability Testing	We conduct cell genetic stability studies in full compliance with ICH guidelines. Our expertise enables us to design and execute a comprehensive testing program tailored to your specific needs and regulatory requirements.
Validation	PCR, Sanger Sequencing
Culture Medium	FBS & Penicillin/Streptomycin & Proline & RPMI
Application	Functional assay
Size	1 M cells/vial*2
Product Format	Frozen
Shipping	Dry ice
Availability Status	Made to order
Handling Notes	Upon receipt, this product must be immediately transferred from dry ice to liquid nitrogen (-150°C to -190°C) and stored in a liquid nitrogen tank. Cell viability is critically dependent on proper handling. We cannot guarantee viability if these instructions are not strictly adhered to.
Product Disclaimer	This product is provided for research only, not suitable for human or animal use. Due to the inherent limitations of infectious agent testing, investigators must exercise extreme caution when handling cells provided by Creative Biolabs, treating all cells as potentially biohazardous.

Target	AVPR1A
Full Name	Arginine Vasopressin Receptor 1A
Alternative Name	V1aR; AVPR1; AVPR V1a
Location	12q14.2
Gene ID	552
Summary	The protein encoded by this gene acts as receptor for arginine vasopressin. This receptor belongs to the subfamily of G-protein coupled receptors which includes AVPR1B, V2R and OXT receptors. Its activity is mediated by G proteins which stimulate a phosphatidylinositol-calcium second messenger system. The receptor mediates cell contraction and proliferation, platelet aggregation, release of coagulation factor and glycogenolysis.