GlycoErase™ AVPR1A Knockout HEK293T Cell Line (CAT#: GLJF-0825-JF501)

Description	GlycoErase™ AVPR1A knockout HEK293T cell line is a human embryonic kidney (HEK293T) model in which AVPR1A has been deleted. AVPR1A encodes a vasopressin GPCR that couples to phospholipase C to drive IP3-dependent Ca²⁺ mobilization, influencing contraction, platelet activation, glycogenolysis, and proliferation. In HEK293T cells, receptor loss creates a clean human platform for GPCR signal transduction analysis, Ca²⁺ imaging assays, biased agonism/protean ligand studies, and cardiovascular or hemostasis-relevant pharmacology.
Product Type	KO Cell Lines
Species	Human
Cell Morphology	Epithelial-like, adherent
Passage Ratio	1:2~1:4
Cell Line	HEK293T
Lineage	Embryonic kidney

Cell Viability	>90%
Sterility Test	The sterility test indicated an absence of microbial growth.
Identity Test	STR identification
Mycoplasma Test	Negative
Virus Test	Negative for HIV, HBV and HCV.
Genetic Stability Testing	We conduct cell genetic stability studies in full compliance with ICH guidelines. Our expertise enables us to design and execute a comprehensive testing program tailored to your specific needs and regulatory requirements.
Validation	PCR, Sanger Sequencing
Culture Medium	DMEM & FBS & Penicillin/Streptomycin
Application	Functional assay
Size	1 M cells/vial*2
Product Format	Frozen
Shipping	Dry ice
Availability Status	Made to order
Handling Notes	Upon receipt, this product must be immediately transferred from dry ice to liquid nitrogen (-150°C to -190°C) and stored in a liquid nitrogen tank. Cell viability is critically dependent on proper handling. We cannot guarantee viability if these instructions are not strictly adhered to.
Product Disclaimer	This product is provided for research only, not suitable for human or animal use. Due to the inherent limitations of infectious agent testing, investigators must exercise extreme caution when handling cells provided by Creative Biolabs, treating all cells as potentially biohazardous.

Target	AVPR1A
Full Name	Arginine Vasopressin Receptor 1A
Alternative Name	V1aR; AVPR1; AVPR V1a
Location	12q14.2
Gene ID	552
Summary	The vasopressin receptor AVPR1A is part of the GPCR family and stimulates a phosphatidylinositol-calcium second messenger system. It mediates cell contraction, platelet aggregation, and glycogenolysis.