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GlycoErase™ C1GALT1 Knockout Human Glioma Cell A172

CAT#: GLJF-0525-JF775

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Overview Specification Target Information Related Products
Overview
Description
The C1GALT1 knockout A172 cell line presents a unique model for examining the role of Core 1 O-glycosylation in glioma biology, as the absence of C1GALT1 hinders the synthesis of Core 1 O-glycans, allowing researchers to analyze the impact of altered O-glycosylation on the tumor microenvironment, metastatic processes, and the identification of O-glycosylatioN-related therapeutic targets or drugs.
Product Type
KO Cell Lines
Species
Human
Cell Morphology
Epithelial-like, adherent
Passage Ratio
1:2~1:3
Cell Line
A172
Primary Disease
Diffuse Glioma
Lineage
CNS/Brain
Specification
Cell Viability
>90%
Sterility Test
The sterility test indicated an absence of microbial growth.
Identity Test
STR identification
Mycoplasma Test
Negative
Virus Test
Negative for HIV, HBV and HCV.
Genetic Stability Testing
We conduct cell genetic stability studies in full compliance with ICH guidelines. Our expertise enables us to design and execute a comprehensive testing program tailored to your specific needs and regulatory requirements.
Validation
PCR, Sanger Sequencing
Culture Medium
DMEM & FBS & Glutamine
Application
Functional assay
Size
1 M cells/vial*2
Product Format
Frozen
Shipping
Dry ice
Availability Status
Made to order
Handling Notes
Upon receipt, this product must be immediately transferred from dry ice to liquid nitrogen (-150°C to -190°C) and stored in a liquid nitrogen tank. Cell viability is critically dependent on proper handling. We cannot guarantee viability if these instructions are not strictly adhered to.
Product Disclaimer
This product is provided for research only, not suitable for human or animal use. Due to the inherent limitations of infectious agent testing, investigators must exercise extreme caution when handling cells provided by Creative Biolabs, treating all cells as potentially biohazardous.
Target Information
Target
C1GALT1
Full Name
Core 1 synthase, glycoprotein-N-acetylgalactosamine 3-Beta-galactosyltransferase 1
Alternative Name
C1GALT, T-synthase
Location
7p22.1-p21.3
Gene ID
56913
Summary
Synthesizes core 1 O-glycan (Gal-beta-1-3GalNAc-R) via Gal transfer (UDP-Gal to GalNAc-alpha-1-R); precursor for mucin-type O-glycans (cell surface & secreted) involved in cell signaling and interactions.
For Research Use Only.
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