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GlycoErase™ CPT2 Knockout HepG2 Cell Line

CAT#: GLJF-0825-JF620

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Overview Specification Target Information Related Products
Overview
Description
GlycoErase™ CPT2 knockout HepG2 cell line eliminates CPT2, a mitochondrial enzyme working with CPT1 to catalyze long-chain fatty acid oxidation. CPT2 mutations cause fatty acid oxidation disorders. This knockout provides a hepatic platform for studying mitochondrial fatty acid metabolism, energy balance, and metabolic diseases, supporting applications in mitochondrial biology, lipid metabolism, and rare disease research.
Product Type
KO Cell Lines
Species
Human
Cell Morphology
Epithelial-like, adherent
Passage Ratio
1:4~1:6
Cell Line
HepG2
Primary Disease
Hepatoblastoma
Lineage
Liver
Lineage Subtype
Hepatoblastoma
Specification
Cell Viability
>90%
Sterility Test
The sterility test indicated an absence of microbial growth.
Identity Test
STR identification
Mycoplasma Test
Negative
Virus Test
Negative for HIV, HBV and HCV.
Genetic Stability Testing
We conduct cell genetic stability studies in full compliance with ICH guidelines. Our expertise enables us to design and execute a comprehensive testing program tailored to your specific needs and regulatory requirements.
Validation
PCR, Sanger Sequencing
Culture Medium
DMEM & FBS & Glutamine
Application
Functional assay
Size
1 M cells/vial*2
Product Format
Frozen
Shipping
Dry ice
Availability Status
Made to order
Handling Notes
Upon receipt, this product must be immediately transferred from dry ice to liquid nitrogen (-150°C to -190°C) and stored in a liquid nitrogen tank. Cell viability is critically dependent on proper handling. We cannot guarantee viability if these instructions are not strictly adhered to.
Product Disclaimer
This product is provided for research only, not suitable for human or animal use. Due to the inherent limitations of infectious agent testing, investigators must exercise extreme caution when handling cells provided by Creative Biolabs, treating all cells as potentially biohazardous.
Target Information
Target
CPT2
Full Name
Carnitine Palmitoyltransferase 2
Alternative Name
CPT1; IIAE4; CPTASE
Location
1p32.3
Gene ID
1376
Summary
This nuclear protein is transported to the mitochondrial inner membrane, where it works with carnitine palmitoyltransferase I to oxidize long-chain fatty acids. Mutations cause mitochondrial long-chain fatty acid oxidation disorders.
For Research Use Only.
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