GlycoErase™ DPY19L3 Knockout KD Cell Line (CAT#: GLJF-0425-JF651)

Description	The DPY19L3 knockout KD cell line, derived from an extra-cranial rhabdoid tumor, lacks the DPY19L3 protein, a dpy-19 like C-mannosyltransferase 3 involved in protein glycosylation in the ER membrane. DPY19L3 knockout in rhabdoid cancer cells can be used to study ER-localized protein glycosylation changes in this pediatric sarcoma context, impacting protein folding, trafficking, and potentially interactions within the ER microenvironment.
Product Type	KO Cell Lines
Species	Human
Cell Morphology	Epithelial-like, adherent
Passage Ratio	1:2~1:4
Cell Line	KD cell line
Primary Disease	Rhabdoid cancer
Lineage	Soft Tissue
Lineage Subtype	Rhabdoid cancer

Cell Viability	>90%
Sterility Test	The sterility test indicated an absence of microbial growth.
Identity Test	STR identification
Mycoplasma Test	Negative
Virus Test	Negative for HIV, HBV and HCV.
Genetic Stability Testing	We conduct cell genetic stability studies in full compliance with ICH guidelines. Our expertise enables us to design and execute a comprehensive testing program tailored to your specific needs and regulatory requirements.
Validation	PCR, Sanger Sequencing
Culture Medium	F-12 & FBS & Penicillin/Streptomycin
Application	Functional assay
Size	2 M cells/vial*2
Product Format	Frozen
Shipping	Dry ice
Availability Status	Made to order
Handling Notes	Upon receipt, this product must be immediately transferred from dry ice to liquid nitrogen (-150°C to -190°C) and stored in a liquid nitrogen tank. Cell viability is critically dependent on proper handling. We cannot guarantee viability if these instructions are not strictly adhered to.
Product Disclaimer	This product is provided for research only, not suitable for human or animal use. Due to the inherent limitations of infectious agent testing, investigators must exercise extreme caution when handling cells provided by Creative Biolabs, treating all cells as potentially biohazardous.

Target	DPY19L3
Full Name	Dpy-19 like C-mannosyltransferase 3
Alternative Name	DPY-19-like 3
Location	19q13.11
Gene ID	147991
Summary	Mannosyltransferase predicted to be involved in protein glycosylation within the endoplasmic reticulum.