GlycoErase™ FUCA1 Knockout Human Bladder Cancer Cell 5637 (CAT#: GLJF-0525-JF14)

Description	Absence of FUCA1, the lysosomal alpha-L-fucosidase 1 involved in the degradation of fucosylated glycans, in 5637 cells may impair lysosomal glycan processing, providing a model to study altered lysosomal glycan metabolism in bladder cancer cells and its consequences for cellular functions and nutrient recycling.
Product Type	KO Cell Lines
Species	Human
Cell Morphology	Epithelial-like, adherent
Passage Ratio	1:3~1:6
Cell Line	5637
Primary Disease	Bladder Urothelial Carcinoma
Lineage	Bladder/Urinary Tract

Cell Viability	>90%
Sterility Test	The sterility test indicated an absence of microbial growth.
Identity Test	STR identification
Mycoplasma Test	Negative
Virus Test	Negative for HIV, HBV and HCV.
Genetic Stability Testing	We conduct cell genetic stability studies in full compliance with ICH guidelines. Our expertise enables us to design and execute a comprehensive testing program tailored to your specific needs and regulatory requirements.
Validation	PCR, Sanger Sequencing
Culture Medium	FBS & Penicillin/Streptomycin & RPMI
Application	Functional assay
Size	1 M cells/vial*2
Product Format	Frozen
Shipping	Dry ice
Availability Status	Made to order
Handling Notes	Upon receipt, this product must be immediately transferred from dry ice to liquid nitrogen (-150°C to -190°C) and stored in a liquid nitrogen tank. Cell viability is critically dependent on proper handling. We cannot guarantee viability if these instructions are not strictly adhered to.
Product Disclaimer	This product is provided for research only, not suitable for human or animal use. Due to the inherent limitations of infectious agent testing, investigators must exercise extreme caution when handling cells provided by Creative Biolabs, treating all cells as potentially biohazardous.

Target	FUCA1
Full Name	Alpha-L-fucosidase 1
Alternative Name	Fucosidase alpha 1, Fucosidase alpha-L 1, Alpha-L-fucosidase
Location	1p36.11
Gene ID	2517
Summary	Lysosomal enzyme responsible for degrading fucose-containing glycoproteins and glycolipids; mutations cause fucosidosis (FUCA1D), a lysosomal storage disorder.