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GlycoErase™ FUCA1 Knockout KD Cell Line

CAT#: GLJF-0425-JF654

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Overview Specification Target Information Related Products
Overview
Description
The FUCA1 knockout KD cell line, derived from an extra-cranial rhabdoid tumor, lacks FUCA1 protein, lysosomal alpha-L-fucosidase 1 involved in lysosomal degradation of fucosylated glycans. FUCA1 knockout in rhabdoid cancer cells may impair lysosomal glycan processing. This model can study altered lysosomal glycan metabolism in rhabdoid cancer cells and its impact on cellular functions and nutrient recycling in this pediatric sarcoma.
Product Type
KO Cell Lines
Species
Human
Cell Morphology
Epithelial-like, adherent
Passage Ratio
1:2~1:4
Cell Line
KD cell line
Primary Disease
Rhabdoid cancer
Lineage
Soft Tissue
Lineage Subtype
Rhabdoid cancer
Specification
Cell Viability
>90%
Sterility Test
The sterility test indicated an absence of microbial growth.
Identity Test
STR identification
Mycoplasma Test
Negative
Virus Test
Negative for HIV, HBV and HCV.
Genetic Stability Testing
We conduct cell genetic stability studies in full compliance with ICH guidelines. Our expertise enables us to design and execute a comprehensive testing program tailored to your specific needs and regulatory requirements.
Validation
PCR, Sanger Sequencing
Culture Medium
F-12 & FBS & Penicillin/Streptomycin
Application
Functional assay
Size
1 M cells/vial*2
Product Format
Frozen
Shipping
Dry ice
Availability Status
Made to order
Handling Notes
Upon receipt, this product must be immediately transferred from dry ice to liquid nitrogen (-150°C to -190°C) and stored in a liquid nitrogen tank. Cell viability is critically dependent on proper handling. We cannot guarantee viability if these instructions are not strictly adhered to.
Product Disclaimer
This product is provided for research only, not suitable for human or animal use. Due to the inherent limitations of infectious agent testing, investigators must exercise extreme caution when handling cells provided by Creative Biolabs, treating all cells as potentially biohazardous.
Target Information
Target
FUCA1
Full Name
Alpha-L-fucosidase 1
Alternative Name
Fucosidase alpha 1, Fucosidase alpha-L 1, Alpha-L-fucosidase
Location
1p36.11
Gene ID
2517
Summary
Lysosomal enzyme responsible for degrading fucose-containing glycoproteins and glycolipids; mutations cause fucosidosis (FUCA1D), a lysosomal storage disorder.
For Research Use Only.
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