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GlycoErase™ GBE1 Knockout HEK293T Cell Line

CAT#: GLJF-0825-JF514

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Overview Specification Target Information Related Products
Overview
Description
GlycoErase™ GBE1 knockout HEK293T cell line is a HEK293T model in which GBE1 has been removed. GBE1 encodes the glycogen branching enzyme that introduces α-1,6 linkages, ensuring glycogen solubility and storage efficiency. Deficiency leads to Andersen's disease (glycogen storage disease IV). The knockout supports analysis of glycogen architecture, solubility, and osmotic balance in a human system, offering a platform for therapeutic discovery in glycogen storage disorders.
Product Type
KO Cell Lines
Species
Human
Cell Morphology
Epithelial-like, adherent
Passage Ratio
1:2~1:4
Cell Line
HEK293T
Lineage
Embryonic kidney
Specification
Cell Viability
>90%
Sterility Test
The sterility test indicated an absence of microbial growth.
Identity Test
STR identification
Mycoplasma Test
Negative
Virus Test
Negative for HIV, HBV and HCV.
Genetic Stability Testing
We conduct cell genetic stability studies in full compliance with ICH guidelines. Our expertise enables us to design and execute a comprehensive testing program tailored to your specific needs and regulatory requirements.
Validation
PCR, Sanger Sequencing
Culture Medium
DMEM & FBS & Penicillin/Streptomycin
Application
Functional assay
Size
1 M cells/vial*2
Product Format
Frozen
Shipping
Dry ice
Availability Status
Made to order
Handling Notes
Upon receipt, this product must be immediately transferred from dry ice to liquid nitrogen (-150°C to -190°C) and stored in a liquid nitrogen tank. Cell viability is critically dependent on proper handling. We cannot guarantee viability if these instructions are not strictly adhered to.
Product Disclaimer
This product is provided for research only, not suitable for human or animal use. Due to the inherent limitations of infectious agent testing, investigators must exercise extreme caution when handling cells provided by Creative Biolabs, treating all cells as potentially biohazardous.
Target Information
Target
GBE1
Full Name
1,4-Alpha-Glucan Branching Enzyme 1
Alternative Name
GBE; APBD; GSD4
Location
3p12.2
Gene ID
2632
Summary
The protein encoded by this gene is a glycogen branching enzyme that transfers glucosyl units to create branches in glycogen chains, increasing its solubility. This enzyme is highly expressed in liver and muscle, and mutations cause glycogen storage disease IV (Andersen's disease).
For Research Use Only.
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