GlycoErase™ GSK3A Knockout HEK293T Cell Line (CAT#: GLJF-0825-JF520)

Description	GlycoErase™ GSK3A knockout HEK293T cell line is a human model lacking GSK3A expression. GSK3A encodes a serine/threonine kinase that regulates glycogen synthase, JUN activity, and WNT/PI3K signaling. It has also been implicated in Alzheimer's disease via amyloid-beta peptide production. Disruption of GSK3A in HEK293T cells creates a versatile system for studying kinase signaling, glycogen control, and neurodegenerative processes, with applications in oncology, metabolism, and therapeutic discovery.
Product Type	KO Cell Lines
Species	Human
Cell Morphology	Epithelial-like, adherent
Passage Ratio	1:2~1:4
Cell Line	HEK293T
Lineage	Embryonic kidney

Cell Viability	>90%
Sterility Test	The sterility test indicated an absence of microbial growth.
Identity Test	STR identification
Mycoplasma Test	Negative
Virus Test	Negative for HIV, HBV and HCV.
Genetic Stability Testing	We conduct cell genetic stability studies in full compliance with ICH guidelines. Our expertise enables us to design and execute a comprehensive testing program tailored to your specific needs and regulatory requirements.
Validation	PCR, Sanger Sequencing
Culture Medium	DMEM & FBS & Penicillin/Streptomycin
Application	Functional assay
Size	1 M cells/vial*2
Product Format	Frozen
Shipping	Dry ice
Availability Status	Made to order
Handling Notes	Upon receipt, this product must be immediately transferred from dry ice to liquid nitrogen (-150°C to -190°C) and stored in a liquid nitrogen tank. Cell viability is critically dependent on proper handling. We cannot guarantee viability if these instructions are not strictly adhered to.
Product Disclaimer	This product is provided for research only, not suitable for human or animal use. Due to the inherent limitations of infectious agent testing, investigators must exercise extreme caution when handling cells provided by Creative Biolabs, treating all cells as potentially biohazardous.

Target	GSK3A
Full Name	Glycogen Synthase Kinase 3 Alpha
Location	19q13.2
Gene ID	2931
Summary	This gene encodes a Ser/Thr kinase that regulates glycogen synthase and transcription factors, including JUN. It is involved in the WNT and PI3K signaling pathways and regulates beta-amyloid peptides, associated with Alzheimer's disease.