GlycoErase™ GYG1 Knockout HEK293 Cell Line (CAT#: GLJF-0825-JF406)

Description	GlycoErase™ GYG1 knockout HEK293 cell line is a HEK293 model in which GYG1 expression has been eliminated. GYG1 encodes glycogenin, a glycosyltransferase that autoglucosylates to initiate glycogen biosynthesis, later extended by glycogen synthase and branching enzyme. Mutations cause glycogen storage disease XV. This knockout provides a human-based platform to explore glycogen initiation, skeletal muscle-related glycogen storage disorders, and inherited metabolic pathologies, supporting studies in metabolic regulation and therapeutic discovery.
Product Type	KO Cell Lines
Species	Human
Cell Morphology	Epithelial-like, adherent
Passage Ratio	1:2~1:4
Cell Line	HEK293
Lineage	Embryonic kidney

Cell Viability	>90%
Sterility Test	The sterility test indicated an absence of microbial growth.
Identity Test	STR identification
Mycoplasma Test	Negative
Virus Test	Negative for HIV, HBV and HCV.
Genetic Stability Testing	We conduct cell genetic stability studies in full compliance with ICH guidelines. Our expertise enables us to design and execute a comprehensive testing program tailored to your specific needs and regulatory requirements.
Validation	PCR, Sanger Sequencing
Culture Medium	FBS & Penicillin/Streptomycin & Proline & RPMI
Application	Functional assay
Size	1 M cells/vial*2
Product Format	Frozen
Shipping	Dry ice
Availability Status	Made to order
Handling Notes	Upon receipt, this product must be immediately transferred from dry ice to liquid nitrogen (-150°C to -190°C) and stored in a liquid nitrogen tank. Cell viability is critically dependent on proper handling. We cannot guarantee viability if these instructions are not strictly adhered to.
Product Disclaimer	This product is provided for research only, not suitable for human or animal use. Due to the inherent limitations of infectious agent testing, investigators must exercise extreme caution when handling cells provided by Creative Biolabs, treating all cells as potentially biohazardous.

Target	GYG1
Full Name	Glycogenin 1
Alternative Name	GYG; GSD15
Location	3q24
Gene ID	2992
Summary	This gene encodes glycogenin, a glycosyltransferase that catalyzes the formation of a short glucose polymer in glycogen synthesis. This gene is expressed in muscle and other tissues, and mutations cause glycogen storage disease XV. Pseudogenes exist on chromosomes 1, 8, and 13.