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GlycoErase™ GYS2 Knockout HEK293T Cell Line

CAT#: GLJF-0825-JF525

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Overview Specification Target Information Related Products
Overview
Description
GlycoErase™ GYS2 knockout HEK293T cell line is a human model lacking GYS2 expression. GYS2 encodes the liver isoform of glycogen synthase, the rate-limiting enzyme in hepatic glycogen biosynthesis. Loss-of-function mutations cause glycogen storage disease type 0, characterized by fasting hypoglycemia. The knockout in HEK293T provides a system to study hepatic glycogen regulation, energy balance, and childhood metabolic disease in a human cellular setting.
Product Type
KO Cell Lines
Species
Human
Cell Morphology
Epithelial-like, adherent
Passage Ratio
1:2~1:4
Cell Line
HEK293T
Lineage
Embryonic kidney
Specification
Cell Viability
>90%
Sterility Test
The sterility test indicated an absence of microbial growth.
Identity Test
STR identification
Mycoplasma Test
Negative
Virus Test
Negative for HIV, HBV and HCV.
Genetic Stability Testing
We conduct cell genetic stability studies in full compliance with ICH guidelines. Our expertise enables us to design and execute a comprehensive testing program tailored to your specific needs and regulatory requirements.
Validation
PCR, Sanger Sequencing
Culture Medium
DMEM & FBS & Penicillin/Streptomycin
Application
Functional assay
Size
1 M cells/vial*2
Product Format
Frozen
Shipping
Dry ice
Availability Status
Made to order
Handling Notes
Upon receipt, this product must be immediately transferred from dry ice to liquid nitrogen (-150°C to -190°C) and stored in a liquid nitrogen tank. Cell viability is critically dependent on proper handling. We cannot guarantee viability if these instructions are not strictly adhered to.
Product Disclaimer
This product is provided for research only, not suitable for human or animal use. Due to the inherent limitations of infectious agent testing, investigators must exercise extreme caution when handling cells provided by Creative Biolabs, treating all cells as potentially biohazardous.
Target Information
Target
GYS2
Full Name
Glycogen Synthase 2
Location
12p12.1
Gene ID
2998
Summary
This gene encodes liver glycogen synthase, catalyzing the transfer of glucose to the glycogen molecule during synthesis. Mutations cause glycogen storage disease type 0, characterized by fasting hypoglycemia and low liver glycogen.
For Research Use Only.
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