GlycoErase™ HEK293F-ΔC1GALT1C1 Cell Line (CAT#: GLJF-0425-JF264)

Description	This C1GALT1C1 knockout (HEK293F) cell line lacks the C1GALT1C1 protein, a C1GALT1-specific chaperone 1. This gene encodes a type II transmembrane protein that is similar to the core 1 beta1,3-galactosyltransferase 1, which catalyzes the synthesis of the core-1 structure, also known as T-antigen. Loss of C1GALT1C1 function may impair proper folding and activity of C1GALT1, disrupting O-linked glycosylation and potential cellular signaling.
Product Type	KO Cell Lines
Species	Human
Cell Morphology	Epithelial-like, adherent
Passage Ratio	1:2~1:4
Cell Line	HEK293F
Lineage	Embryonic kidney

Cell Viability	>90%
Sterility Test	The sterility test indicated an absence of microbial growth.
Identity Test	STR identification
Mycoplasma Test	Negative
Virus Test	Negative for HIV, HBV and HCV.
Genetic Stability Testing	We conduct cell genetic stability studies in full compliance with ICH guidelines. Our expertise enables us to design and execute a comprehensive testing program tailored to your specific needs and regulatory requirements.
Validation	PCR, Sanger Sequencing
Culture Medium	DMEM
Application	Functional assay
Size	2 M cells/vial*2
Product Format	Frozen
Shipping	Dry ice
Availability Status	Made to order
Handling Notes	Upon receipt, this product must be immediately transferred from dry ice to liquid nitrogen (-150°C to -190°C) and stored in a liquid nitrogen tank. Cell viability is critically dependent on proper handling. We cannot guarantee viability if these instructions are not strictly adhered to.
Product Disclaimer	This product is provided for research only, not suitable for human or animal use. Due to the inherent limitations of infectious agent testing, investigators must exercise extreme caution when handling cells provided by Creative Biolabs, treating all cells as potentially biohazardous.

Target	C1GALT1C1
Full Name	C1GALT1 specific chaperone 1
Alternative Name	C1GALT2, COSMC
Location	Xq24
Gene ID	29071
Summary	Facilitates the synthesis of the core-1 O-glycan structure (Thomsen-Friedenreich antigen) by acting as a chaperone for core 1 beta1,3-galactosyltransferase 1, ensuring proper folding and activity of this key enzyme.