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GlycoErase™ HEK293F-ΔFUCA2 Cell Line

CAT#: GLJF-0425-JF271

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Overview Specification Target Information Related Products
Overview
Description
This FUCA2 knockout (HEK293F) cell line lacks the FUCA2 protein, an alpha-L-fucosidase 2. This gene encodes a plasma alpha-L-fucosidase, which represents 10-20% of the total cellular fucosidase activity. The protein is a member of the glycosyl hydrolase 29 family, and catalyzes the hydrolysis of terminal alpha-L-fucose residues from fucosylated glycoconjugates. Loss of FUCA2 function may alter the extracellular processing of fucosylated glycans.
Product Type
KO Cell Lines
Species
Human
Cell Morphology
Epithelial-like, adherent
Passage Ratio
1:2~1:4
Cell Line
HEK293F
Lineage
Embryonic kidney
Specification
Cell Viability
>90%
Sterility Test
The sterility test indicated an absence of microbial growth.
Identity Test
STR identification
Mycoplasma Test
Negative
Virus Test
Negative for HIV, HBV and HCV.
Genetic Stability Testing
We conduct cell genetic stability studies in full compliance with ICH guidelines. Our expertise enables us to design and execute a comprehensive testing program tailored to your specific needs and regulatory requirements.
Validation
PCR, Sanger Sequencing
Culture Medium
DMEM
Application
Functional assay
Size
1 M cells/vial*2
Product Format
Frozen
Shipping
Dry ice
Availability Status
Made to order
Handling Notes
Upon receipt, this product must be immediately transferred from dry ice to liquid nitrogen (-150°C to -190°C) and stored in a liquid nitrogen tank. Cell viability is critically dependent on proper handling. We cannot guarantee viability if these instructions are not strictly adhered to.
Product Disclaimer
This product is provided for research only, not suitable for human or animal use. Due to the inherent limitations of infectious agent testing, investigators must exercise extreme caution when handling cells provided by Creative Biolabs, treating all cells as potentially biohazardous.
Target Information
Target
FUCA2
Full Name
Alpha-L-fucosidase 2
Alternative Name
MGC1314, dJ20N2.5
Location
6q24.2
Gene ID
2519
Summary
Plasma alpha-L-fucosidase responsible for 10-20% of cellular fucosidase activity; hydrolyzes alpha-1,6-linked fucose on glycoproteins; essential for Helicobacter pylori adhesion to gastric cancer cells.
For Research Use Only.
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