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GlycoErase™ HEK293F-ΔPMM2 Cell Line

CAT#: GLJF-0425-JF326

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Overview Specification Target Information Related Products
Overview
Description
This PMM2 knockout (HEK293F) cell line lacks the PMM2 protein, a phosphomannomutase 2. The protein encoded by this gene catalyzes the isomerization of mannose 6-phosphate to mannose 1-phosphate, which is a precursor of GDP-mannose necessary for the synthesis of dolichol-P-linked oligosaccharide. Loss of PMM2 function may disrupt dolichol-linked oligosaccharide synthesis.
Product Type
KO Cell Lines
Species
Human
Cell Morphology
Epithelial-like, adherent
Passage Ratio
1:2~1:4
Cell Line
HEK293F
Lineage
Embryonic kidney
Specification
Cell Viability
>90%
Sterility Test
The sterility test indicated an absence of microbial growth.
Identity Test
STR identification
Mycoplasma Test
Negative
Virus Test
Negative for HIV, HBV and HCV.
Genetic Stability Testing
We conduct cell genetic stability studies in full compliance with ICH guidelines. Our expertise enables us to design and execute a comprehensive testing program tailored to your specific needs and regulatory requirements.
Validation
PCR, Sanger Sequencing
Culture Medium
DMEM
Application
Functional assay
Size
1 M cells/vial*2
Product Format
Frozen
Shipping
Dry ice
Availability Status
Made to order
Handling Notes
Upon receipt, this product must be immediately transferred from dry ice to liquid nitrogen (-150°C to -190°C) and stored in a liquid nitrogen tank. Cell viability is critically dependent on proper handling. We cannot guarantee viability if these instructions are not strictly adhered to.
Product Disclaimer
This product is provided for research only, not suitable for human or animal use. Due to the inherent limitations of infectious agent testing, investigators must exercise extreme caution when handling cells provided by Creative Biolabs, treating all cells as potentially biohazardous.
Target Information
Target
PMM2
Full Name
Phosphomannomutase 2
Alternative Name
CDG1, CDGS, PMI1, CDG1a, PMI
Gene ID
5373
Summary
Catalyzes the isomerization of mannose 6-phosphate to mannose 1-phosphate, a precursor for GDP-mannose synthesis, essential for dolichol-P-oligosaccharide formation.
For Research Use Only.
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