GlycoErase™ HEK293T MAN2B1 Knockout Cell Line (CAT#: GLJF-0425-JF440)

Description	For researchers exploring carbohydrate catabolism, we are pleased to offer a MAN2B1 knockout HEK293T cell line. This model lacks the MAN2B1-encoded mannosidase alpha class 2B member 1, an enzyme necessary for the catabolism of N-linked carbohydrates. By disrupting MAN2B1 function, this cell line provides a valuable tool for understanding the consequences of impaired carbohydrate catabolism and its impact on cellular processes.
Product Type	KO Cell Lines
Species	Human
Cell Morphology	Epithelial-like, adherent
Passage Ratio	1:2~1:4
Cell Line	HEK293T
Lineage	Embryonic kidney

Cell Viability	>90%
Sterility Test	The sterility test indicated an absence of microbial growth.
Identity Test	STR identification
Mycoplasma Test	Negative
Virus Test	Negative for HIV, HBV and HCV.
Genetic Stability Testing	We conduct cell genetic stability studies in full compliance with ICH guidelines. Our expertise enables us to design and execute a comprehensive testing program tailored to your specific needs and regulatory requirements.
Validation	PCR, Sanger Sequencing
Culture Medium	DMEM & FBS & Penicillin/Streptomycin
Application	Functional assay
Size	1 M cells/vial*2
Product Format	Frozen
Shipping	Dry ice
Availability Status	Made to order
Handling Notes	Upon receipt, this product must be immediately transferred from dry ice to liquid nitrogen (-150°C to -190°C) and stored in a liquid nitrogen tank. Cell viability is critically dependent on proper handling. We cannot guarantee viability if these instructions are not strictly adhered to.
Product Disclaimer	This product is provided for research only, not suitable for human or animal use. Due to the inherent limitations of infectious agent testing, investigators must exercise extreme caution when handling cells provided by Creative Biolabs, treating all cells as potentially biohazardous.

Target	MAN2B1
Full Name	Mannosidase alpha class 2B member 1
Alternative Name	LAMAN, MANB
Location	19p13.13
Gene ID	4125
Summary	Hydrolyzes terminal alpha-D-mannose residues in alpha-D-mannosides; essential for N-linked carbohydrate catabolism during glycoprotein turnover.