GlycoErase™ HEK293T UGT1A1 Knockout Cell Line

To further expand the tools available for studying glucuronidation, we are pleased to offer a UGT1A1 knockout HEK293T cell line. This cell line, deficient in the UGT1A1-encoded UDP glucuronosyltransferase 1 family member A1, provides a unique opportunity to investigate the role of glucuronidation in detoxification and metabolism of various compounds. This model, within the context of HEK293T cells, a platform widely used for gene function and regulation studies, allows for in-depth analysis of UGT1A1's contribution to the glucuronidation pathway.

KO Cell Lines

Human

Epithelial-like, adherent

1:2~1:4

HEK293T

Embryonic kidney

>90%

The sterility test indicated an absence of microbial growth.

STR identification

Negative

Negative for HIV, HBV and HCV.

We conduct cell genetic stability studies in full compliance with ICH guidelines. Our expertise enables us to design and execute a comprehensive testing program tailored to your specific needs and regulatory requirements.

PCR, Sanger Sequencing

DMEM & FBS & Penicillin/Streptomycin

Functional assay

1 M cells/vial*2

Frozen

Dry ice

Made to order

Upon receipt, this product must be immediately transferred from dry ice to liquid nitrogen (-150°C to -190°C) and stored in a liquid nitrogen tank. Cell viability is critically dependent on proper handling. We cannot guarantee viability if these instructions are not strictly adhered to.

This product is provided for research only, not suitable for human or animal use. Due to the inherent limitations of infectious agent testing, investigators must exercise extreme caution when handling cells provided by Creative Biolabs, treating all cells as potentially biohazardous.

UGT1A1

Dolutegravir (HIV integrase inhibitor)

UDP glucuronosyltransferase family 1 member A1

UGT1, UGT1A, GNT1

2q37.1

UDP-glucuronosyltransferase involved in the glucuronidation pathway, converting lipophilic molecules into water-soluble metabolites for excretion.