GlycoErase™ MAN2B1 Knockout Human Thyroid Carcinoma Cell 8305C (CAT#: GLJF-0525-JF696)

Description	The MAN2B1 knockout 8305C cell line, lacking mannosidase alpha class 2B member 1 involved in the catabolism of N-linked carbohydrates, allows for the investigation of carbohydrate catabolism disruption in thyroid carcinoma, potentially affecting N-glycan turnover, lysosomal glycan processing, and cellular nutrient recycling, which are critical in thyroid carcinoma cell metabolism.
Product Type	KO Cell Lines
Species	Human
Cell Morphology	Large spindle-shaped cell, adherent
Passage Ratio	1:3~1:6
Cell Line	8305C
Primary Disease	Anaplastic Thyroid Cancer
Lineage	Thyroid

Cell Viability	>90%
Sterility Test	The sterility test indicated an absence of microbial growth.
Identity Test	STR identification
Mycoplasma Test	Negative
Virus Test	Negative for HIV, HBV and HCV.
Genetic Stability Testing	We conduct cell genetic stability studies in full compliance with ICH guidelines. Our expertise enables us to design and execute a comprehensive testing program tailored to your specific needs and regulatory requirements.
Validation	PCR, Sanger Sequencing
Culture Medium	FBS & RPMI
Application	Functional assay
Size	1 M cells/vial*2
Product Format	Frozen
Shipping	Dry ice
Availability Status	Made to order
Handling Notes	Upon receipt, this product must be immediately transferred from dry ice to liquid nitrogen (-150°C to -190°C) and stored in a liquid nitrogen tank. Cell viability is critically dependent on proper handling. We cannot guarantee viability if these instructions are not strictly adhered to.
Product Disclaimer	This product is provided for research only, not suitable for human or animal use. Due to the inherent limitations of infectious agent testing, investigators must exercise extreme caution when handling cells provided by Creative Biolabs, treating all cells as potentially biohazardous.

Target	MAN2B1
Full Name	Mannosidase alpha class 2B member 1
Alternative Name	LAMAN, MANB
Location	19p13.13
Gene ID	4125
Summary	Hydrolyzes terminal alpha-D-mannose residues in alpha-D-mannosides; essential for N-linked carbohydrate catabolism during glycoprotein turnover.