GlycoErase™ SLC37A4 Knockout HEK293 Cell Line (CAT#: GLJF-0825-JF483)

Description	GlycoErase™ SLC37A4 knockout HEK293 cell line is a HEK293 model lacking SLC37A4 expression. SLC37A4 encodes the ER glucose-6-phosphate transporter that shuttles G6P into the ER lumen, essential for glucose homeostasis and Ca²⁺ sequestration. Mutations cause glycogen storage disease type Ib. The knockout in a human-derived background provides a system to investigate ER-glucose flux, glycogen storage disorders, and ER-calcium coupling, supporting metabolic disorder modeling and transporter-targeted drug discovery.
Product Type	KO Cell Lines
Species	Human
Cell Morphology	Epithelial-like, adherent
Passage Ratio	1:2~1:4
Cell Line	HEK293
Lineage	Embryonic kidney

Cell Viability	>90%
Sterility Test	The sterility test indicated an absence of microbial growth.
Identity Test	STR identification
Mycoplasma Test	Negative
Virus Test	Negative for HIV, HBV and HCV.
Genetic Stability Testing	We conduct cell genetic stability studies in full compliance with ICH guidelines. Our expertise enables us to design and execute a comprehensive testing program tailored to your specific needs and regulatory requirements.
Validation	PCR, Sanger Sequencing
Culture Medium	FBS & Penicillin/Streptomycin & Proline & RPMI
Application	Functional assay
Size	1 M cells/vial*2
Product Format	Frozen
Shipping	Dry ice
Availability Status	Made to order
Handling Notes	Upon receipt, this product must be immediately transferred from dry ice to liquid nitrogen (-150°C to -190°C) and stored in a liquid nitrogen tank. Cell viability is critically dependent on proper handling. We cannot guarantee viability if these instructions are not strictly adhered to.
Product Disclaimer	This product is provided for research only, not suitable for human or animal use. Due to the inherent limitations of infectious agent testing, investigators must exercise extreme caution when handling cells provided by Creative Biolabs, treating all cells as potentially biohazardous.

Target	SLC37A4
Full Name	Solute Carrier Family 37 Member 4
Alternative Name	G6PT; SPX4; CDG2W; G6PT1; G6PT2; G6PT3; GSD1b; GSD1c; GSD1d; TRG19; TRG-19; PRO0685
Location	11q23.3
Gene ID	2542
Summary	This gene transports glucose-6-phosphate from the cytoplasm into the ER lumen to maintain glucose homeostasis and participates in ATP-mediated calcium sequestration. Mutations cause glycogen storage disease. Multiple isoforms are produced.