GlycoErase™ UGT1A1 Knockout Human Renal Cell Adenocarcinoma Cell 769-P (CAT#: GLJF-0525-JF488)

Description	The UGT1A1 deficient human renal cell adenocarcinoma cell 769-P line, lacking UGT1A1 protein involved in glucuronidation processes, enables investigation of how glucuronidation disruption affects renal cell adenocarcinoma, influencing detoxification pathways and glycaN-dependent functions in tumor cells.
Product Type	KO Cell Lines
Species	Human
Cell Morphology	Epithelial-like, adherent
Passage Ratio	1:4~1:12
Cell Line	769-P
Primary Disease	Renal Cell Carcinoma
Lineage	Kidney

Cell Viability	>90%
Sterility Test	The sterility test indicated an absence of microbial growth.
Identity Test	STR identification
Mycoplasma Test	Negative
Virus Test	Negative for HIV, HBV and HCV.
Genetic Stability Testing	We conduct cell genetic stability studies in full compliance with ICH guidelines. Our expertise enables us to design and execute a comprehensive testing program tailored to your specific needs and regulatory requirements.
Validation	PCR, Sanger Sequencing
Culture Medium	Glutamine & NaHCO₃ & RPMI
Application	Functional assay
Size	1 M cells/vial*2
Product Format	Frozen
Shipping	Dry ice
Availability Status	Made to order
Handling Notes	Upon receipt, this product must be immediately transferred from dry ice to liquid nitrogen (-150°C to -190°C) and stored in a liquid nitrogen tank. Cell viability is critically dependent on proper handling. We cannot guarantee viability if these instructions are not strictly adhered to.
Product Disclaimer	This product is provided for research only, not suitable for human or animal use. Due to the inherent limitations of infectious agent testing, investigators must exercise extreme caution when handling cells provided by Creative Biolabs, treating all cells as potentially biohazardous.

Target	UGT1A1
Compounds Targeting	Dolutegravir (HIV integrase inhibitor)
Full Name	UDP glucuronosyltransferase family 1 member A1
Alternative Name	UGT1, UGT1A, GNT1
Location	2q37.1
Gene ID	54658
Summary	UDP-glucuronosyltransferase involved in the glucuronidation pathway, converting lipophilic molecules into water-soluble metabolites for excretion.