GlycoErase™ UGT3A1 Knockout Human Lung Cancer Cell A-427 (CAT#: GLJF-0525-JF1385)

Description	The UGT1A1 deficient human lung cancer cell A-427, characterized by the absence of a protein exhibiting glucuronosyltransferase activity and constituting a component of the UDP-N-acetylglucosamine transferase complex, further supports the investigation into the functional consequences of disrupted glucuronidation and UDP-N-acetylglucosamine transferase activity within the context of lung adenocarcinoma, underscoring the potential for UGT1A1 to exert multifaceted roles in tumor cell metabolism and glycosylation pathways.
Product Type	KO Cell Lines
Species	Human
Cell Morphology	Epithelial-like, adherent
Passage Ratio	1:2~1:3
Cell Line	A-427
Primary Disease	Non-Small Cell Lung Cancer
Lineage	Lung

Cell Viability	>90%
Sterility Test	The sterility test indicated an absence of microbial growth.
Identity Test	STR identification
Mycoplasma Test	Negative
Virus Test	Negative for HIV, HBV and HCV.
Genetic Stability Testing	We conduct cell genetic stability studies in full compliance with ICH guidelines. Our expertise enables us to design and execute a comprehensive testing program tailored to your specific needs and regulatory requirements.
Validation	PCR, Sanger Sequencing
Culture Medium	FBS & RPMI
Application	Functional assay
Size	1 M cells/vial*2
Product Format	Frozen
Shipping	Dry ice
Availability Status	Made to order
Handling Notes	Upon receipt, this product must be immediately transferred from dry ice to liquid nitrogen (-150°C to -190°C) and stored in a liquid nitrogen tank. Cell viability is critically dependent on proper handling. We cannot guarantee viability if these instructions are not strictly adhered to.
Product Disclaimer	This product is provided for research only, not suitable for human or animal use. Due to the inherent limitations of infectious agent testing, investigators must exercise extreme caution when handling cells provided by Creative Biolabs, treating all cells as potentially biohazardous.

Target	UGT3A1
Compounds Targeting	Kaempferol (bone resorption inhibitor, estrogen-related receptor inverse agonist) Quercetin (polar auxin transport inhibitor)
Full Name	UDP glycosyltransferase family 3 member A1
Alternative Name	FLJ34658
Location	5p13.2
Gene ID	133688
Summary	Glucuronosyltransferase that is part of the UDP-N-acetylglucosamine transferase complex, contributing to glycosylation processes.