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GlycoFlux™ AAV1-Human PGM3 Viral Particle (CAT#: GLJF-1025-JF972)

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SPECIFIC INQUIRY
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Description GlycoFlux™ AAV1-PGM3 Viral Particle provides sustained PGM3 expression to support bidirectional G1P↔G6P transfer and evaluate variants linked to diabetic complication resistance; this product targets liver and central nervous system for prolonged systems-glycobiology readouts and is furnished as a replication-defective reagent for research use only.
Product Type Recombinant AAV1
Target PGM3
Species Human
Promotor CMV, CAG, TRE, or other promoters
Tissue Tropism Smooth muscle, Central Nervous System (CNS), Retina, Pancreas, Inner Ear, Heart, Liver
Packaging System AAV Triple-Plasmid Transfection System
Packaging Cell HEK293T
Application This AAV1 viral particle is primarily used for overexpressing target genes in muscle tissues (smooth muscle, heart) and the central nervous system (CNS) / sensory organs (retina, inner ear). It is an ideal tool for research and pre-clinical studies focused on myopathies, cardiac disorders, and certain neurological or sensory genetic diseases.
Shipping Shipped on dry ice, with temperature maintained at ≤ -80°C.
Storage Store at -80°C to preserve viral titer and stability.
Handling Notes Store this product at -80°C and minimize freeze-thaw cycles to preserve viral titer. For safety, handle in a certified biological safety cabinet and wear appropriate PPE (lab coat, gloves, and eye protection).
Product Disclaimer This product is intended for research use only and is not approved for diagnostic procedures or clinical applications. Users are solely responsible for implementing appropriate safety practices and complying with all applicable laws, regulations, and institutional policies. While Creative Biolabs is committed to rigorous quality control, no guarantee is made regarding performance in any particular assay or application.
Titer Assay qPCR/TCID50
Mycoplasma Test No mycoplasma contamination was detected.
Sterility Sterility testing verified the absence of microbial contamination.
Transduction Evaluation Upon request, Creative Biolabs performs in vitro or in vivo transduction assays to assess AAV delivery to target cells and to quantify transgene expression and function.
Insert Identity Confirmation All AAV preparations from Creative Biolabs are verified for vector-genome identity by PCR. In this assay, target cells are transduced with serial dilutions of the AAV preparation, harvested after a short incubation, and genomic DNA is isolated; a defined region of the packaged transgene is then PCR-amplified to confirm the expected sequence.
Full Name Phosphoglucomutase 3
Alternative Name AGM1; PAGM; IMD23; PGM 3
Location 6q14.1
Gene ID 5238
Summary This gene encodes a member of the phosphohexose mutase family. The encoded protein mediates both glycogen formation and utilization by catalyzing the interconversion of glucose-1-phosphate and glucose-6-phosphate. A non-synonymous single nucleotide polymorphism in this gene may play a role in resistance to diabetic nephropathy and neuropathy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
For Research Use Only.
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